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    Dhx37 DEAH-box helicase 37 [ Mus musculus (house mouse) ]

    Gene ID: 208144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx37provided by MGI
    Official Full Name
    DEAH-box helicase 37provided by MGI
    Primary source
    MGI:MGI:3028576
    See related
    Ensembl:ENSMUSG00000029480 AllianceGenome:MGI:3028576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm451; Gm1050; mKIAA1517
    Summary
    Predicted to enable U3 snoRNA binding activity and helicase activity. Predicted to be involved in brain development; positive regulation of male gonad development; and ribosome biogenesis. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.3), adrenal adult (RPKM 9.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx37 in Genome Data Viewer
    Location:
    5 G1.1; 5 64.2 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125490811..125511203, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125413747..125434139, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2179 Neighboring gene STARR-positive B cell enhancer ABC_E3623 Neighboring gene nuclear encoded tRNA aspartic acid 14 (anticodon GTC) Neighboring gene nuclear encoded tRNA alanine 5 (anticodon TGC) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125921729-125921912 Neighboring gene Bri3 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene predicted gene, 40325

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. Boneberg FM, et al. RNA, 2019 Jun. PMID 30910870, Free PMC Article
    2. Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Sferruzzi-Perri AN, et al. Biol Reprod, 2009 Jul. PMID 19228596, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1517, MGC90028

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U3 snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DHX37
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 37
    NP_976064.1
    XP_017176254.1
    XP_030110171.1
    XP_036020844.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203319.2 → NP_976064.1  probable ATP-dependent RNA helicase DHX37

      See identical proteins and their annotated locations for NP_976064.1

      Status: VALIDATED

      Source sequence(s)
      AC138613
      Consensus CDS
      CCDS19685.1
      UniProtKB/TrEMBL
      Q5DTX1, Q6NZL1
      Related
      ENSMUSP00000131734.2, ENSMUST00000169485.6
      Conserved Domains (6) summary
      smart00490
      Location:578 → 667
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:761 → 852
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:236 → 1009
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:267 → 407
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam04408
      Location:730 → 781
      HA2; Helicase associated domain (HA2)
      pfam07717
      Location:887 → 1004
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RNA

    1. NR_184665.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138613

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      125490811..125511203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320765.2 → XP_017176254.1  probable ATP-dependent RNA helicase DHX37 isoform X1

      UniProtKB/TrEMBL
      Q5DTX1
      Conserved Domains (1) summary
      COG1643
      Location:236 → 1009
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    2. XM_030254311.2 → XP_030110171.1  probable ATP-dependent RNA helicase DHX37 isoform X2

      Conserved Domains (1) summary
      COG1643
      Location:1 → 607
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    3. XM_036164951.1 → XP_036020844.1  probable ATP-dependent RNA helicase DHX37 isoform X3

      Conserved Domains (1) summary
      COG1643
      Location:74 → 503
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_003955608.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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