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    Poln DNA polymerase N [ Mus musculus (house mouse) ]

    Gene ID: 272158, updated on 3-Dec-2024

    Summary

    Official Symbol
    Polnprovided by MGI
    Official Full Name
    DNA polymerase Nprovided by MGI
    Primary source
    MGI:MGI:2675617
    See related
    Ensembl:ENSMUSG00000045102 AllianceGenome:MGI:2675617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POL4P
    Summary
    Predicted to enable DNA-directed DNA polymerase activity and cyclin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and translesion synthesis. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleoplasm. Is expressed in stomach and testis. Orthologous to human POLN (DNA polymerase nu). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 3.7), CNS E11.5 (RPKM 2.7) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Poln in Genome Data Viewer
    Location:
    5 B2; 5 17.83 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34164523..34326870, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34007179..34169526, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NELL2 interacting cell ontogeny regulator 1 Neighboring gene N-acetyltransferase 8-like Neighboring gene STARR-seq mESC enhancer starr_12835 Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene Max dimerization protein 4 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase nu
    Names
    DNA-directed DNA polymerase nu

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289803.2NP_001276732.2  DNA polymerase nu isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107709, AC157989
      Consensus CDS
      CCDS80262.1
      UniProtKB/TrEMBL
      A0A0J9YVA9
      Related
      ENSMUSP00000144578.2, ENSMUST00000202409.2
    2. NM_001289804.2NP_001276733.2  DNA polymerase nu isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107709, AC157989
      Consensus CDS
      CCDS80263.1
      UniProtKB/TrEMBL
      A0A0J9YTQ3
      Related
      ENSMUSP00000143793.2, ENSMUST00000202638.4
    3. NM_181857.5NP_862905.2  DNA polymerase nu isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107709, AC157989
      Consensus CDS
      CCDS39067.1
      UniProtKB/Swiss-Prot
      Q3V0L3, Q7TQ07
      UniProtKB/TrEMBL
      A0A0R4J0E3
      Related
      ENSMUSP00000036110.8, ENSMUST00000042954.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34164523..34326870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)