Mcm9 minichromosome maintenance 9 homologous recombination repair factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcm9provided by MGI
Official Full Name: minichromosome maintenance 9 homologous recombination repair factorprovided by MGI
Primary source: MGI:MGI:1918817
See related: Ensembl:ENSMUSG00000058298 AllianceGenome:MGI:1918817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm235; Mcmdc1; 9030408O17Rik
Summary: Enables chromatin binding activity. Involved in DNA repair and female gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including brain; genitourinary system; liver; neural retina; and spleen. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in ovarian dysgenesis 4. Orthologous to human MCM9 (minichromosome maintenance 9 homologous recombination repair factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.4), liver E14 (RPKM 2.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 27.21 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (53412411..53507251, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (53536315..53630006, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
Title: MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9
Title: MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
MCM8 and MCM9 form a complex and that they coregulate their stability.
Title: MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Title: Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
Title: Identification of a novel cell-cycle-induced MCM family protein MCM9.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236352

RH126491 (e-PCR)
- UniSTS:163199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables MutLbeta complex binding	IEA Inferred from Electronic Annotation more info
enables MutLbeta complex binding	ISO Inferred from Sequence Orthology more info
enables MutSalpha complex binding	IEA Inferred from Electronic Annotation more info
enables MutSalpha complex binding	ISO Inferred from Sequence Orthology more info
enables MutSbeta complex binding	IEA Inferred from Electronic Annotation more info
enables MutSbeta complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
NOT involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in female gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in recombinational interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recombinational interstrand cross-link repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM8-MCM9 complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM8-MCM9 complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA helicase MCM9

Names: DNA replication licensing factor MCM9; mini-chromosome maintenance deficient 9; mini-chromosome maintenance deficient domain-containing protein 1; minichromosome maintenance complex component 9

NP_082106.3

EC 3.6.4.12

XP_006512919.1

EC 3.6.4.12

XP_006512920.1

EC 3.6.4.12

XP_011241508.1

EC 3.6.4.12

XP_017169587.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027830.3 → NP_082106.3 DNA helicase MCM9

Status: VALIDATED

Source sequence(s)

AC153949, AC155941

Consensus CDS

CCDS23846.2

UniProtKB/Swiss-Prot

Q2KHI9, Q3V370, Q6P6J6, Q9D344

Related

ENSMUSP00000157761.2, ENSMUST00000237608.2

Conserved Domains (2) summary

COG1241
Location:10 → 605

Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

cl25751
Location:739 → 1004

DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

53412411..53507251 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314098.3 → XP_017169587.1 DNA helicase MCM9 isoform X1

Conserved Domains (2) summary

PTZ00449
Location:384 → 649

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl28901
Location:30 → 248

MCM; MCM helicase family
XM_011243206.2 → XP_011241508.1 DNA helicase MCM9 isoform X2

See identical proteins and their annotated locations for XP_011241508.1

Conserved Domains (2) summary

PTZ00449
Location:365 → 630

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl28901
Location:10 → 229

MCM; MCM helicase family
XM_006512857.5 → XP_006512920.1 DNA helicase MCM9 isoform X4

UniProtKB/TrEMBL

A0A1W2P804

Related

ENSMUSP00000151639.3, ENSMUST00000219838.3

Conserved Domains (1) summary

COG1241
Location:10 → 383

Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
XM_006512856.5 → XP_006512919.1 DNA helicase MCM9 isoform X3

UniProtKB/TrEMBL

A0A1W2P804

Related

ENSMUSP00000151893.3, ENSMUST00000218549.3

Conserved Domains (1) summary

COG1241
Location:10 → 383

Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]