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    Cd33 CD33 molecule [ Mus musculus (house mouse) ]

    Gene ID: 12489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd33provided by MGI
    Official Full Name
    CD33 moleculeprovided by MGI
    Primary source
    MGI:MGI:99440
    See related
    Ensembl:ENSMUSG00000004609 AllianceGenome:MGI:99440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gp67; Siglec-3
    Summary
    Predicted to enable protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to several human genes including CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E18 (RPKM 4.3), mammary gland adult (RPKM 4.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd33 in Genome Data Viewer
    Location:
    7 B3; 7 28.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43176823..43186679, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43527399..43537424, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9278 Neighboring gene Siglec family like 1 Neighboring gene zinc finger protein 658 Neighboring gene STARR-positive B cell enhancer ABC_E9290 Neighboring gene zinc finger protein 719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen. Tchilian EZ, et al. Blood, 1994 Jun 1. PMID 8193354
    2. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Brinkman-Van der Linden EC, et al. Mol Cell Biol, 2003 Jun. PMID 12773563, Free PMC Article
    3. Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice. Gnoth K, et al. Biomolecules, 2022 Mar 4. PMID 35327591, Free PMC Article
    4. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. Duan S, et al. J Clin Invest, 2019 Mar 1. PMID 30645205, Free PMC Article
    5. CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis. Tan S, et al. Neuromolecular Med, 2023 Jun. PMID 36639554

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
      Title: CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
    2. Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
      Title: Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
    3. knockout of CD33 attenuated amyloid beta (Abeta) pathologyand improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Differential gene expression in 5xFAD;CD33(-/-) microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1beta/IL-1RN axis and a gene set in the "receptor activity chemokine"...
      Title: TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
    4. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
      Title: CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
    5. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
      Title: Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
    6. CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
      Title: Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.
    7. mCD33 is expressed on myeloid precursors in the bone marrow
      Title: CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.
    8. SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly.
      Title: CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid cell surface antigen CD33
    Names
    CD33 antigen
    sialic acid-binding Ig-like lectin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111058.1 → NP_001104528.1  myeloid cell surface antigen CD33 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001104528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC154108
      Consensus CDS
      CCDS52224.1
      UniProtKB/Swiss-Prot
      A2RT59, Q63994, Q63997
      Related
      ENSMUSP00000004728.6, ENSMUST00000004728.12
      Conserved Domains (2) summary
      cd00096
      Location:21 → 25
      Ig; Ig strand A [structural motif]
      cl11960
      Location:21 → 139
      Ig; Immunoglobulin domain

    2. NM_021293.3 → NP_067268.1  myeloid cell surface antigen CD33 isoform 2 precursor

      See identical proteins and their annotated locations for NP_067268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK155745, BC132379
      Consensus CDS
      CCDS21173.1
      UniProtKB/Swiss-Prot
      Q63994
      Related
      ENSMUSP00000146225.2, ENSMUST00000205503.2
      Conserved Domains (2) summary
      smart00410
      Location:26 → 119
      IG_like; Immunoglobulin like
      cl11960
      Location:21 → 139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43176823..43186679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540590.4 → XP_006540653.1  myeloid cell surface antigen CD33 isoform X1

      See identical proteins and their annotated locations for XP_006540653.1

      Conserved Domains (1) summary
      cl11960
      Location:46 → 164
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63994.1 GenPept UniProtKB/Swiss-Prot:Q63994

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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