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    Snrpb2 U2 small nuclear ribonucleoprotein B [ Mus musculus (house mouse) ]

    Gene ID: 20639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snrpb2provided by MGI
    Official Full Name
    U2 small nuclear ribonucleoprotein Bprovided by MGI
    Primary source
    MGI:MGI:104805
    See related
    Ensembl:ENSMUSG00000008333 AllianceGenome:MGI:104805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810052G09Rik
    Summary
    Predicted to enable U1 snRNA binding activity and snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic ribonucleoprotein granule; fibrillar center; and nuclear speck. Predicted to be part of U1 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in 8-cell stage embryo; central nervous system; olfactory epithelium; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 38.4), CNS E14 (RPKM 22.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snrpb2 in Genome Data Viewer
    Location:
    2 G1; 2 70.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (142904989..142913972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143063069..143072052)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kinesin family member 16B Neighboring gene STARR-seq mESC enhancer starr_05876 Neighboring gene STARR-positive B cell enhancer mm9_chr2:142638896-142639197 Neighboring gene predicted gene, 22310 Neighboring gene STARR-positive B cell enhancer ABC_E5991 Neighboring gene STARR-positive B cell enhancer ABC_E4505 Neighboring gene STARR-positive B cell enhancer ABC_E2049 Neighboring gene kinesin family member 16B, opposite strand Neighboring gene STARR-seq mESC enhancer starr_05877 Neighboring gene STARR-positive B cell enhancer ABC_E3408 Neighboring gene STARR-seq mESC enhancer starr_05878 Neighboring gene STARR-seq mESC enhancer starr_05879 Neighboring gene otoraplin Neighboring gene predicted gene 14083

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. U2-snRNP B" protein gene is an early growth-inducible gene. Laitinen J, et al. J Cell Biochem, 1995 Aug. PMID 7593271
    2. Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. Matsuoka T, et al. J Reprod Dev, 2008 Jun. PMID 18360097
    3. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Tucker KE, et al. J Cell Biol, 2001 Jul 23. PMID 11470819, Free PMC Article
    4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
    5. The biogenesis of the coiled body during early mouse development. Ferreira J, et al. Development, 1995 Feb. PMID 7768196

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snRNP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snRNP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein B''
    Names
    U2 snRNP B''

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021335.3 → NP_067310.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_067310.1

      Status: PROVISIONAL

      Source sequence(s)
      AK013871
      Consensus CDS
      CCDS16808.1
      UniProtKB/Swiss-Prot
      Q9CQI7, Q9CW35, Q9CZ66
      Related
      ENSMUSP00000008477.7, ENSMUST00000008477.13
      Conserved Domains (2) summary
      cd12478
      Location:6 → 96
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins
      cd12481
      Location:146 → 225
      RRM2_U2B; RNA recognition motif 2 found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      142904989..142913972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQI7.1 GenPept UniProtKB/Swiss-Prot:Q9CQI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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