Ddx5 DEAD box helicase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx5provided by MGI
Official Full Name: DEAD box helicase 5provided by MGI
Primary source: MGI:MGI:105037
See related: Ensembl:ENSMUSG00000020719 AllianceGenome:MGI:105037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p68; Hlr1; G17P1; HUMP68; 2600009A06Rik
Summary: Enables RNA binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including RNA metabolic process; regulation of alternative mRNA splicing, via spliceosome; and regulation of osteoblast differentiation. Acts upstream of or within circadian rhythm; positive regulation of DNA-templated transcription; and protein import into nucleus. Predicted to be located in nuclear speck and nucleolus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 253.6), CNS E14 (RPKM 165.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 70.01 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106671181..106680011, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106780355..106789185, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MCM8 interacts with DDX5 to promote R-loop resolution.
Title: MCM8 interacts with DDX5 to promote R-loop resolution.
DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Title: DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
Title: Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation.
Title: Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation.
RNA binding protein DDX5 restricts RORgammat[+] Treg suppressor function to promote intestine inflammation.
Title: RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation.
The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant.
Title: The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant.
RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
Title: RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.
Title: RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.
RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
Title: RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cbeta to deactivate IRF3.
Title: RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC102575P1 (e-PCR)
- UniSTS:270088

WI-22548 (e-PCR)
- UniSTS:77080

R74704 (e-PCR)
- UniSTS:125512

D17S1990 (e-PCR)
- UniSTS:2178

RH141897 (e-PCR)
- UniSTS:223889

Ddx5 (e-PCR), detects polymorphism
- UniSTS:527309

Ddx5 (e-PCR), detects polymorphism
- UniSTS:506841

NoName (e-PCR)
- UniSTS:236764

AI118346 (e-PCR)
- UniSTS:180446

AA858847 (e-PCR)
- UniSTS:243426

DDX5 (e-PCR)
- UniSTS:266725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables MH2 domain binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of viral genome replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX5

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box RNA helicase DEAD1; DEAD box protein 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; RNA helicase p68; mDEAD1

NP_001342605.1

EC 3.6.4.13

NP_001342606.1

EC 3.6.4.13

NP_031866.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355676.1 → NP_001342605.1 probable ATP-dependent RNA helicase DDX5

Status: VALIDATED

Source sequence(s)

AK166698, BC062916, CJ173936

Consensus CDS

CCDS25562.1

UniProtKB/TrEMBL

A1L333, Q6P5F8, Q8BTS0

Conserved Domains (2) summary

pfam08061
Location:551 → 583

P68HR; P68HR (NUC004) repeat

cl26939
Location:6 → 507

DEXDc; DEAD-like helicases superfamily
NM_001355677.1 → NP_001342606.1 probable ATP-dependent RNA helicase DDX5

Status: VALIDATED

Source sequence(s)

AL603664, BC062916

Consensus CDS

CCDS25562.1

UniProtKB/TrEMBL

A1L333, Q6P5F8, Q8BTS0

Conserved Domains (2) summary

pfam08061
Location:551 → 583

P68HR; P68HR (NUC004) repeat

cl26939
Location:6 → 507

DEXDc; DEAD-like helicases superfamily
NM_007840.3 → NP_031866.2 probable ATP-dependent RNA helicase DDX5

See identical proteins and their annotated locations for NP_031866.2

Status: VALIDATED

Source sequence(s)

AK166045

Consensus CDS

CCDS25562.1

UniProtKB/TrEMBL

A1L333, Q6P5F8, Q8BTS0

Related

ENSMUSP00000021062.6, ENSMUST00000021062.12

Conserved Domains (2) summary

pfam08061
Location:551 → 583

P68HR; P68HR (NUC004) repeat

cl26939
Location:6 → 507

DEXDc; DEAD-like helicases superfamily