Ltk leukocyte tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ltkprovided by MGI
Official Full Name: leukocyte tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:96840
See related: Ensembl:ENSMUSG00000027297 AllianceGenome:MGI:96840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]
Expression: Broad expression in cortex adult (RPKM 11.7), frontal lobe adult (RPKM 7.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.97 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119581807..119590912, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119751326..119760431, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis
Title: Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
Title: The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

M90470 (e-PCR)
- UniSTS:159006

Ltk (e-PCR), detects polymorphism
- UniSTS:143801

Ltk (e-PCR), detects polymorphism
- UniSTS:143802

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte tyrosine kinase receptor

Names: leukocyte receptor tyrosine kinase

NP_032549.2

EC 2.7.10.1

NP_976220.2

EC 2.7.10.1

NP_996824.1

EC 2.7.10.1

NP_996825.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008523.2 → NP_032549.2 leukocyte tyrosine kinase receptor isoform A

See identical proteins and their annotated locations for NP_032549.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is lacking several exons from the 5' end, and an internal coding exon compared to transcript variant 4. This results in a shorter isoform (A), which has a different N-terminus, is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is specifically expressed in the lymphocytes and initiates translation from a non-AUG (CUG) start codon.

Source sequence(s)

BC047138

Consensus CDS

CCDS50674.1

UniProtKB/TrEMBL

A0A804AW03, Q0VGZ5

Related

ENSMUSP00000138201.3, ENSMUST00000182203.3

Conserved Domains (2) summary

cd05036
Location:187 → 463

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam07714
Location:194 → 461

Pkinase_Tyr; Protein tyrosine kinase
NM_203345.2 → NP_976220.2 leukocyte tyrosine kinase receptor isoform D precursor

See identical proteins and their annotated locations for NP_976220.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (D), is expressed in neuroblastoma cells, and initiates translation from the standard AUG start codon.

Source sequence(s)

AL844536, BC047138, M90470

Consensus CDS

CCDS16608.1

UniProtKB/Swiss-Prot

A2AQ22, P08923

UniProtKB/TrEMBL

B9EJ30

Related

ENSMUSP00000028759.7, ENSMUST00000028759.13

Conserved Domains (2) summary

cd05036
Location:499 → 775

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam07714
Location:506 → 773

Pkinase_Tyr; Protein tyrosine kinase
NM_206941.1 → NP_996824.1 leukocyte tyrosine kinase receptor isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing several exons from the 5' end, and has a different 5' end exon compared to transcript variant 4. This results in a shorter isoform (B) with a different N-terminus compared to isoform D. This variant is specifically expressed in the brain and initiates translation from a non-AUG (CUG) start codon.

Source sequence(s)

BC047138, M90470

UniProtKB/TrEMBL

A0A804AW03

Conserved Domains (2) summary

cd05036
Location:248 → 524

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam07714
Location:255 → 522

Pkinase_Tyr; Protein tyrosine kinase
NM_206942.2 → NP_996825.2 leukocyte tyrosine kinase receptor isoform C precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) is lacking an internal coding exon compared to transcript variant 4. This results in an isoform (C), which is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is expressed in neuroblastoma cells and initiates translation from the standard AUG start codon.

Source sequence(s)

AL844536, BC047138, M90470

Consensus CDS

CCDS16609.1

UniProtKB/TrEMBL

B9EJ30

Related

ENSMUSP00000080774.7, ENSMUST00000082130.13

Conserved Domains (2) summary

cd05036
Location:438 → 714

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam07714
Location:445 → 712

Pkinase_Tyr; Protein tyrosine kinase