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    HOT13 Hot13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853778, updated on 9-Dec-2024

    Summary

    Official Symbol
    HOT13
    Official Full Name
    Hot13p
    Primary source
    SGD:S000001567
    Locus tag
    YKL084W
    See related
    AllianceGenome:SGD:S000001567; FungiDB:YKL084W; VEuPathDB:YKL084W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion binding activity. Involved in protein import into mitochondrial intermembrane space. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See HOT13 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (280509..280859)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1 Neighboring gene ribosome biosynthesis protein RRP14 Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into mitochondrial intermembrane space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Hot13p
    NP_012839.1
    • Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      280509..280859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179650.1NP_012839.1  TPA: Hot13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK4, P36078, Q6Q598
      UniProtKB/TrEMBL
      B3LR08, C8ZC89, G2WHU9, N1P7S4
      Conserved Domains (1) summary
      COG4357
      Location:3111
      COG4357; Uncharacterized protein, contains Zn-finger domain of CHY type [Function unknown]