STE6 ATP-binding cassette a-factor transporter STE6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STE6
Official Full Name: ATP-binding cassette a-factor transporter STE6
Primary source: SGD:S000001692
Locus tag: YKL209C
See related: AllianceGenome:SGD:S000001692; FungiDB:YKL209C; VEuPathDB:YKL209C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ABC-type peptide transporter activity. Involved in peptide pheromone export. Located in Golgi apparatus; mating projection tip; and plasma membrane. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See STE6 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (42423..46295, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsp70/40s act before ubiquitination and facilitate Ste6p association with E3 ubiquitin ligase, suggesting an active role for chaperones. Furthermore, polyubiquitination was a prerequisite for retrotranslocation, which required the Cdc48 complex and ATP.
Title: Dissecting the ER-associated degradation of a misfolded polytopic membrane protein.
Ste6p follows the PURE pathway--a general pathway for the internalization of plasma membrane proteins that involves phosphorylation, ubiquitination, recognition and endocytosis
Title: The internalization of yeast Ste6p follows an ordered series of events involving phosphorylation, ubiquitination, recognition and endocytosis.
Ubp1 has a role in sorting the ATP-binding cassette-transporter Ste6 in the endocytic pathway
Title: The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway.
STE6 recycling is controlled by ubiquinination in the early endocytic pathway.
Title: Control of Ste6 recycling by ubiquitination in the early endocytic pathway in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type oligopeptide transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type peptide transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type peptide transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oligopeptide export from mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in peptide pheromone export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-binding cassette a-factor transporter STE6

NP_012713.1

EC 7.4.2.7

Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

42423..46295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179774.1 → NP_012713.1 TPA: ATP-binding cassette a-factor transporter STE6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012713.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWZ4, P12866

UniProtKB/TrEMBL

A7A080, B3LQQ0, C7GJ04, G2WHI5, N1P2D0

Conserved Domains (1) summary

COG1132
Location:702 → 1289

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]