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    VPS24 ESCRT-III subunit protein VPS24 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853825, updated on 3-Nov-2024

    Summary

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    Official Symbol
    VPS24
    Official Full Name
    ESCRT-III subunit protein VPS24
    Primary source
    SGD:S000001524
    Locus tag
    YKL041W
    See related
    AllianceGenome:SGD:S000001524; FungiDB:YKL041W; VEuPathDB:YKL041W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DID3; VPL26
    Summary
    Involved in ATP export; intralumenal vesicle formation; and late endosome to vacuole transport. Located in cytoplasm. Part of ESCRT III complex. Orthologous to human RNF103-CHMP3 (RNF103-CHMP3 readthrough) and CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VPS24 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (360143..360817)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Phd1p Neighboring gene Spc42p Neighboring gene Nfu1p Neighboring gene Ptm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the VID27 gene prevents suppression of the doa4 degradation defect in doa4Δ did3Δ double mutant. Wolters N, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27939891
    2. Characterization of a novel alternatively spliced human transcript encoding an N-terminally truncated Vps24 protein that suppresses the effects of Bax in an ESCRT independent manner in yeast. Khoury CM, et al. Gene, 2007 Apr 15. PMID 17331679
    3. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. Babst M, et al. EMBO J, 1998 Jun 1. PMID 9606181, Free PMC Article
    4. Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Yang B, et al. Nat Struct Mol Biol, 2015 Jun. PMID 25938660, Free PMC Article
    5. Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. Davies BA, et al. Mol Biol Cell, 2010 Oct 1. PMID 20702581, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Design principles of the ESCRT-III Vps24-Vps2 module.
      Title: Design principles of the ESCRT-III Vps24-Vps2 module.
    2. ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
      Title: ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
    3. Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
      Title: Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
    4. Impact of Vta1 and ESCRT-III family members on Vps4 ATPase activity.
      Title: ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intralumenal vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ESCRT-III subunit protein VPS24
    NP_012883.1
    • One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      360143..360817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179607.1 → NP_012883.1  TPA: ESCRT-III subunit protein VPS24 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXP5, P36095
      UniProtKB/TrEMBL
      B3LR47, B5VMB5, C7GP32, C8ZCC9, N1P7W5
      Conserved Domains (1) summary
      COG5491
      Location:26 → 224
      Did4; Archaeal division protein CdvB, Snf7/Vps24/ESCRT-III family [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36095.1

    Gene LinkOut

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