ONECUT1 one cut homeobox 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ONECUT1provided by HGNC
Official Full Name: one cut homeobox 1provided by HGNC
Primary source: HGNC:HGNC:8138
See related: Ensembl:ENSG00000169856 MIM:604164; AllianceGenome:HGNC:8138
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HNF6; HNF-6; HNF6A
Summary: This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression: Biased expression in liver (RPKM 2.0), gall bladder (RPKM 1.7) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (52755053..52790336, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (50563333..50598640, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (53047250..53082533, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contribution of ONECUT1 variants to different forms of non-autoimmune diabetes mellitus in Italian patients.
Title: Contribution of ONECUT1 variants to different forms of non-autoimmune diabetes mellitus in Italian patients.
Mutations and variants of ONECUT1 in diabetes.
Title: Mutations and variants of ONECUT1 in diabetes.
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Title: Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
HNF6 promoted colorectal cancer cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis.
Title: HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model.
Data show that chromatin regions that contain the ONECUT motif were in- or lowly accessible in fibroblasts and became accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3.
Title: ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.
Reduced HNF6 expression is associated with metastasis of cholangiocarcinoma.
Title: Hepatocyte nuclear factor 6 inhibits the growth and metastasis of cholangiocarcinoma cells by regulating miR-122.
HNF6 is a novel host factor that can restrict hepatitis B virus replication via both transcriptional and posttranscriptional mechanisms.
Title: Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6.
The negative correlation between HNF6 expression and pancreatic cancer progression suggests that HNF6 maintains pancreatic epithelial homeostasis, and that its loss contributes to the progression from intraepithelial neoplasms to ductal adenocarcinoma.
Title: Loss of HNF6 expression correlates with human pancreatic cancer progression.
HNF6 plays an important role in the gene regulation of CYP3A4 during development from the fetal period to the postnatal period.
Title: Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells.
HNF6 inhibits EMT, cell migration, and invasive growth through a mechanism involving the transcriptional activation of p53.
Title: Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of one cut homeobox 1 (ONECUT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G60395 (e-PCR)
- UniSTS:137501

NoName (e-PCR)
- UniSTS:483886

PMC85812P3 (e-PCR)
- UniSTS:273496

WI-18148 (e-PCR)
- UniSTS:77438

G59678 (e-PCR)
- UniSTS:136832

ONECUT1__6113 (e-PCR)
- UniSTS:464518

RH45256 (e-PCR)
- UniSTS:1709

NoName (e-PCR)
- UniSTS:480447

WI-18317 (e-PCR)
- UniSTS:76791

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in endoderm development	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in pancreatic A cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in pancreatic D cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spleen development	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hepatocyte nuclear factor 6

Names: hepatocyte nuclear factor 6, alpha; one cut domain family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004498.4 → NP_004489.1 hepatocyte nuclear factor 6

See identical proteins and their annotated locations for NP_004489.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AA699732, AC016044, BM679470, U96173

Consensus CDS

CCDS10150.1

UniProtKB/Swiss-Prot

B2RTV4, Q99744, Q9UBC0, Q9UMR6

UniProtKB/TrEMBL

B2CNW3

Related

ENSP00000302630.4, ENST00000305901.7

Conserved Domains (2) summary

smart00389
Location:385 → 440

HOX; Homeodomain

pfam02376
Location:290 → 362

CUT; CUT domain

RNA

NR_073510.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AA699732, AC016044, BM679470, BX118406, U96173