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    ARE1 sterol acyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARE1
    Official Full Name
    sterol acyltransferase
    Primary source
    SGD:S000000644
    Locus tag
    YCR048W
    See related
    AllianceGenome:SGD:S000000644; FungiDB:YCR048W; VEuPathDB:YCR048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAT2
    Summary
    Enables ergosterol O-acyltransferase activity and lanosterol O-acyltransferase activity. Involved in sterol metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Chagas disease; cardiomyopathy; and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1) and SOAT1 (sterol O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARE1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (211929..213761)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein IMG1 Neighboring gene 18S rRNA (guanine1575-N7)-methyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rsc6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts. Beopoulos A, et al. Appl Microbiol Biotechnol, 2012 Feb. PMID 21808970, Free PMC Article
    2. Heme-regulated expression of two yeast acyl-CoA:sterol acyltransferases is involved in the specific response of sterol esterification to anaerobiosis. Valachovic M, et al. FEMS Microbiol Lett, 2002 Jan 2. PMID 11786267
    3. Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae. Jensen-Pergakes K, et al. J Bacteriol, 2001 Sep. PMID 11489845, Free PMC Article
    4. Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae. Valachovic M, et al. FEMS Microbiol Lett, 2001 Apr 1. PMID 11287144
    5. An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Saccharomyces cerevisiae. Sandager L, et al. Biochem Soc Trans, 2000 Dec. PMID 11171176

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ergosterol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ergosterol O-acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables lanosterol O-acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables lanosterol O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ergosterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol acyltransferase
    NP_009978.1
    • Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      211929..213761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178762.1 → NP_009978.1  TPA: sterol acyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009978.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR57, P25628
      UniProtKB/TrEMBL
      B3LUB3, C8Z4E1
      Conserved Domains (1) summary
      COG5056
      Location:96 → 610
      ARE1; Acyl-CoA cholesterol acyltransferase [Lipid metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25628.1

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