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    EPB41L4A-AS1 EPB41L4A antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 114915, updated on 17-Sep-2024

    Summary

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    Official Symbol
    EPB41L4A-AS1provided by HGNC
    Official Full Name
    EPB41L4A antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:30749
    See related
    AllianceGenome:HGNC:30749
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIGA1; C5orf26; NCRNA00219
    Expression
    Ubiquitous expression in ovary (RPKM 35.5), endometrium (RPKM 12.6) and 25 other tissues See more
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    Genomic context

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    See EPB41L4A-AS1 in Genome Data Viewer
    Location:
    5q22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112160526..112162501)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112670980..112672955)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111496223..111498198)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuronal regeneration related protein Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 14 Neighboring gene NREP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111326855-111327356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111327357-111327856 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111333199-111334398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22904 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111496090-111497289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111501161-111501838 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:111501839-111502516 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene small nucleolar RNA, H/ACA box 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111553293-111553794 Neighboring gene uncharacterized LOC101927023 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111573109-111573620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Downregulation of lncRNA EPB41L4A-AS1 promotes gastric cancer cell proliferation, migration and invasion. Ma J, et al. BMC Gastroenterol, 2024 Apr 16. PMID 38627627, Free PMC Article
    2. Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56(bright) NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis. Chai W, et al. Clin Immunol, 2023 May. PMID 37024023
    3. IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis. Dong B, et al. Crit Rev Eukaryot Gene Expr, 2023. PMID 36734855
    4. LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer. Yang F, et al. Ann Clin Lab Sci, 2022 Jan. PMID 35181612
    5. Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer. Bin J, et al. J Cell Physiol, 2021 Jan. PMID 32557646

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of lncRNA EPB41L4A-AS1 promotes gastric cancer cell proliferation, migration and invasion.
      Title: Downregulation of lncRNA EPB41L4A-AS1 promotes gastric cancer cell proliferation, migration and invasion.
    2. Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56[bright] NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis.
      Title: Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56(bright) NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis.
    3. IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis.
      Title: IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis.
    4. LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer.
      Title: LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer.
    5. Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
      Title: Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
    6. miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells.
      Title: miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells.
    7. EPB41L4A-AS1 functions as a repressor of the Warburg effect by mediating nucleolar translocation of HDAC2.
      Title: LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2.
    8. vascular calcification-associated factor (VCAF) is present in human calcified arteries but not noncalcified arteries
      Title: Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • EPB41L4A antisense RNA 1 (non-protein coding)
    • transcript induced by growth arrest 1

    Clone Names

    • MGC126893, MGC138282

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015370.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB048207, DA266578

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      112160526..112162501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      112670980..112672955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_053000.1: Suppressed sequence

      Description
      NM_053000.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and currently there is no support for the protein.
    Nucleotide Protein
    Heading Accession and Version

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