U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    azoR FMN dependent NADH:quinone oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947569, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    azoR
    Official Full Name
    FMN dependent NADH:quinone oxidoreductase
    Primary source
    ECOCYC:G6731
    Locus tag
    b1412
    See related
    ASAP:ABE-0004712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    acpD; ECK1405
    Summary
    AzoR was identifed by N-terminal sequencing in an acyl carrier protein phosphodiesterase preparation and mistaken for the acpD gene. [More information is available at EcoGene: EG12695]. The AzoR protein catalyzes the reductive cleavage of azo groups . [More information is available at EcoCyc: G6731].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1482255..1482860, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrolase/methyltransferase domain-containing protein YnbC Neighboring gene phosphatase domain-containing protein YnbD Neighboring gene ATP-dependent 3'->5' RNA helicase HrpA Neighboring gene DUF218 domain-containing protein YdcF

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Escherichia coli azoreductase AzoR Is involved in resistance to thiol-specific stress caused by electrophilic quinones. Liu G, et al. J Bacteriol, 2009 Oct. PMID 19666717, Free PMC Article
    2. Comparison of the effects of NADH- and NADPH-perturbation stresses on the growth of Escherichia coli. Kim S, et al. Curr Microbiol, 2009 Feb. PMID 18953603
    3. Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis. Ito K, et al. J Biol Chem, 2008 May 16. PMID 18337254
    4. Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms. Ito K, et al. J Biol Chem, 2006 Jul 21. PMID 16684776
    5. Crystallization and preliminary X-ray analysis of AzoR (azoreductase) from Escherichia coli. Ito K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Apr 1. PMID 16511052, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of azoR substrate specificity and catalytic mechanism
      Title: Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables azobenzene reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    FMN dependent NADH:quinone oxidoreductase
    NP_415930.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1482255..1482860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415930.1 FMN dependent NADH:quinone oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415930.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MXW8
      Conserved Domains (1) summary
      PRK00170
      Location:1 → 201
      PRK00170; azoreductase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.