Replication interactions
Interaction |
Pubs |
Knockdown of BCA2 by shRNA enhances HIV-1 replication in Jurkat CD4+ T cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
Increased levels of ubiquitinated BCA2 are found in the presence of HIV-1 Gag, suggesting that the auto-ubiquitination activity of BCA2 increases in the absence of target proteins |
PubMed
|
|
gag
|
Replacement of cysteine residues at positions 228 and 231 with alanine in the E3 catalytic domain of BCA2 has no defect in Gag expression or processing, indicating that residues 228 and 231 are required for the antiviral activity of BCA2 |
PubMed
|
|
gag
|
A ligase-dead mutant deltaRING-BCA2 has no defect in Gag expression or processing, indicating that the intact RING-domain is required for the antiviral activity of BCA2 |
PubMed
|
|
gag
|
BCA2 has tetherin-independent antiviral activity, which results in a defect in either Gag expression or processing, impairing virus assembly and release for both HIV-1 and SIV |
PubMed
|
|
gag
|
BCA2 promotes the lysosomal degradation of HIV-1 and SIV Gag proteins and induces changes in the subcellular distribution of Gag |
PubMed
|
|
gag
|
Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with the MA region (residues 1-165) of HIV-1 Gag |
PubMed
|
|
gag
|
BCA2 induces ubiquitination of both HIV-1 and SIV Gag proteins, resulting in lysine residues K113, K114, and K418 in HIV-1 Gag, and K360 and K419 residues in SIV Gag that are ubiquinated |
PubMed
|
|
gag
|
BCA2 co-localizes with HIV-1 Gag in in CD63+ endosomes/lysosomes |
PubMed
|
Vpu
|
vpu
|
HIV-1 Vpu antagonizes the effects of BCA2 on HIV-1 particle production in ""tetherin-positive"" cells |
PubMed
|
capsid
|
gag
|
A significant downregulation in the levels of virion-associated CA is observed in cells expressing BCA2 for both wild-type HIV-1 and Vpu-deficient HIV-1 |
PubMed
|
matrix
|
gag
|
Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with HIV-1 MA but not CA and NC proteins |
PubMed
|
Go to the HIV-1, Human Interaction Database