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    mngA 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945355, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mngA
    Official Full Name
    2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II
    Primary source
    ECOCYC:EG13235
    Locus tag
    b0731
    See related
    ASAP:ABE-0002493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0719; frx; hrsA
    Summary
    MngA is a phosphotransferase type permease. [More information is available at EcoCyc: EG13235].
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    Genomic context

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    Sequence:
    NC_000913.3 (765984..767960)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional repressor MngR Neighboring gene alpha-mannosidase Neighboring gene cytochrome bd-I subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the heat-responsive genes in Escherichia coli. Utsumi R, et al. Biosci Biotechnol Biochem, 1996 Feb. PMID 9063979
    2. Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. Sampaio MM, et al. J Biol Chem, 2004 Feb 13. PMID 14645248
    3. Quantitative whole-genome analysis of DNA-protein interactions by in vivo methylase protection in E. coli. Tavazoie S, et al. Nat Biotechnol, 1998 Jun. PMID 9624689
    4. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043
    5. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Saier MH Jr, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381841, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-phosphocysteine-sugar phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-phosphocysteine-sugar phosphotransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II
    NP_415259.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      765984..767960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415259.1 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415259.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2A2XF03, A0A2S8IDB5, A0A5P0JB58, A0A979GDB9, A0AAN3ME41, J7QYQ5
      Conserved Domains (1) summary
      PRK09765
      Location:21 → 651
      PRK09765; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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