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    JNM1 Jnm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    JNM1
    Official Full Name
    Jnm1p
    Primary source
    SGD:S000004908
    Locus tag
    YMR294W
    See related
    AllianceGenome:SGD:S000004908; FungiDB:YMR294W; VEuPathDB:YMR294W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    INS1; PAC3
    Summary
    A structural constituent of cytoskeleton. Involved in establishment of mitotic spindle orientation and nuclear migration. Part of dynactin complex. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See JNM1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (856966..858087)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Got1p Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit HER2 Neighboring gene Gsr1p Neighboring gene serine C-palmitoyltransferase LCB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle. McMillan JN, et al. J Cell Biol, 1994 Apr. PMID 8138567, Free PMC Article
    2. Alanine scanning of Arp1 delineates a putative binding site for Jnm1/dynamitin and Nip100/p150Glued. Clark SW, et al. Mol Biol Cell, 2005 Sep. PMID 15975903, Free PMC Article
    3. The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function. Wilson RB, et al. Mol Cell Biol, 1991 Jun. PMID 1645449, Free PMC Article
    4. A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Costigan C, et al. Mol Cell Biol, 1992 Mar. PMID 1545797, Free PMC Article
    5. A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Muhua L, et al. Nature, 1998 Jun 4. PMID 9624007, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Jnm1p
    NP_014022.1
    • Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      856966..858087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182802.1 → NP_014022.1  TPA: Jnm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0C1, P36224
      UniProtKB/TrEMBL
      B3LMI2, G2WL03
      Conserved Domains (1) summary
      pfam04912
      Location:175 → 363
      Dynamitin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36224.2

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