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    UBX6 Ubx6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBX6
    Official Full Name
    Ubx6p
    Primary source
    SGD:S000003584
    Locus tag
    YJL048C
    See related
    AllianceGenome:SGD:S000003584; FungiDB:YJL048C; VEuPathDB:YJL048C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CUI2
    Summary
    Involved in sporulation resulting in formation of a cellular spore and ubiquitin-dependent protein catabolic process. Located in nucleus. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UBX6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (347447..348637, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase MTR4 Neighboring gene Chm7p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cullin RTT101

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. Santiago TC, et al. J Biol Chem, 2003 Oct 3. PMID 12871953
    2. Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Decottignies A, et al. Yeast, 2004 Jan 30. PMID 14755638
    3. The UBX domain: a widespread ubiquitin-like module. Buchberger A, et al. J Mol Biol, 2001 Mar 16. PMID 11243799
    4. Diversification at transcription factor binding sites within a species and the implications for environmental adaptation. Ames RM, et al. Mol Biol Evol, 2011 Dec. PMID 21693437
    5. Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. Schuberth C, et al. EMBO Rep, 2004 Aug. PMID 15258615, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubx6p
    NP_012487.1
    • UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      347447..348637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181481.1 → NP_012487.1  TPA: Ubx6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWD5, P47049
      UniProtKB/TrEMBL
      A6ZPS8, B3LQ63, B5VLD1, C7GSU7, C8ZBB2, G2WGW9, N1NZW5
      Conserved Domains (1) summary
      smart00166
      Location:190 → 266
      UBX; Domain present in ubiquitin-regulatory proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47049.1

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