SPT6 chromatin-remodeling histone chaperone SPT6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPT6
Official Full Name: chromatin-remodeling histone chaperone SPT6
Primary source: SGD:S000003348
Locus tag: YGR116W
See related: AllianceGenome:SGD:S000003348; FungiDB:YGR116W; VEuPathDB:YGR116W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRE2; SSN20
Summary: Enables histone binding activity; nucleosome binding activity; and transcription antitermination factor activity, DNA binding. Involved in several processes, including G1/S transition of mitotic cell cycle; nucleosome assembly; and regulation of RNA metabolic process. Located in euchromatin and nucleus. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SPT6 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (720409..724764)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.
Title: Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
Title: Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.
Title: The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.
Spn1 and Its Dynamic Interactions with Spt6, Histones and Nucleosomes.
Title: Spn1 and Its Dynamic Interactions with Spt6, Histones and Nucleosomes.
Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
Title: Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
Title: The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
Title: Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro.
Title: Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro.
The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae.
Title: The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae.
Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications.
Title: Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosome binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription antitermination factor activity, DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription antitermination factor activity, DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription antitermination factor activity, DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA replication origin binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA 3'-end processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription antitermination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription antitermination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chromatin-remodeling histone chaperone SPT6

NP_011631.1

Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability; role in chromatin remodeling and nucleosome assembly; required for initiation of DNA replication, promoting origin licensing through MCM helicase loading; required for fidelity of promoter selection through maintenance of chromatin structure during transcription; required for H3K36 trimethylation but not dimethylation by Set2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

720409..724764

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181245.1 → NP_011631.1 TPA: chromatin-remodeling histone chaperone SPT6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUP7, P23615

UniProtKB/TrEMBL

A6ZUC9, B3LIB3, N1P9W5

Conserved Domains (3) summary

COG2183
Location:346 → 1277

Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]

pfam14632
Location:28 → 128

SPT6_acidic; Acidic N-terminal SPT6

pfam14633
Location:1232 → 1436

SH2_2; SH2 domain