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    MDH1 malate dehydrogenase MDH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MDH1
    Official Full Name
    malate dehydrogenase MDH1
    Primary source
    SGD:S000001568
    Locus tag
    YKL085W
    See related
    AllianceGenome:SGD:S000001568; FungiDB:YKL085W; VEuPathDB:YKL085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-malate dehydrogenase (NAD+) activity and mRNA binding activity. Involved in tricarboxylic acid cycle. Located in mitochondrial matrix. Used to study developmental and epileptic encephalopathy 51. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MDH1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (279123..280127)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene cytochrome c1 heme lyase CYT2 Neighboring gene sulfiredoxin Neighboring gene Hot13p Neighboring gene ribosome biosynthesis protein RRP14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of heterologous forms of malate dehydrogenase in yeast. Steffan JS, et al. Arch Biochem Biophys, 1992 Feb 14. PMID 1731644
    2. Structural and functional effects of mutations altering the subunit interface of mitochondrial malate dehydrogenase. Steffan JS, et al. Arch Biochem Biophys, 1991 Jun. PMID 1898005
    3. Dispensable presequence for cellular localization and function of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae. Thompson LM, et al. J Biol Chem, 1989 Jul 15. PMID 2663847
    4. Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae. Thompson LM, et al. Biochemistry, 1988 Nov 1. PMID 3072021
    5. Isolation and expression of the gene encoding yeast mitochondrial malate dehydrogenase. McAlister-Henn L, et al. J Bacteriol, 1987 Nov. PMID 3312168, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    malate dehydrogenase MDH1
    NP_012838.1
    • Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; mutation in human homolog MDH2 causes early-onset severe encephalopathy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      279123..280127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179651.1 → NP_012838.1  TPA: malate dehydrogenase MDH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012838.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK3, E9P8U0, P17505
      UniProtKB/TrEMBL
      B3LR07, C7GVM5, G2WHU8, N1NZ54
      Conserved Domains (1) summary
      cd01337
      Location:18 → 331
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17505.2

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