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    rihB pyrimidine-specific ribonucleoside hydrolase RihB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946646, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rihB
    Official Full Name
    pyrimidine-specific ribonucleoside hydrolase RihB
    Primary source
    ECOCYC:EG12030
    Locus tag
    b2162
    See related
    ASAP:ABE-0007156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2155; yeiK
    Summary
    The rihB gene encodes a ribonucleoside hydrolase that can utilize both cytidine and uridine, but shows a preference for cytidine . [More information is available at EcoCyc: EG12030].
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    Genomic context

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    Sequence:
    NC_000913.3 (2254245..2255186, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sugar kinase YeiI Neighboring gene putative nucleoside transporter Neighboring gene DNA-binding transcriptional activator YeiL Neighboring gene putative pseudouridine transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for substrate specificity in group I nucleoside hydrolases. Iovane E, et al. Biochemistry, 2008 Apr 15. PMID 18361502
    2. Accurate description of nitrogenous base flexibility in classical molecular dynamics simulations of nucleotides bound to proteins. Fornili A, et al. J Phys Chem B, 2007 Jun 14. PMID 17508739
    3. Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy. Giabbai B, et al. Structure, 2004 May. PMID 15130467
    4. Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK. Giabbai B, et al. Acta Crystallogr D Biol Crystallogr, 2004 Mar. PMID 14993681
    5. YeiL, the third member of the CRP-FNR family in Escherichia coli. Anjum MF, et al. Microbiology (Reading), 2000 Dec. PMID 11101674

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine nucleosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylpyrimidine nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine ribonucleoside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine ribonucleoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrimidine-specific ribonucleoside hydrolase RihB
    NP_416667.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2254245..2255186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416667.1 pyrimidine-specific ribonucleoside hydrolase RihB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416667.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6A6E1, W1WXD6
      Conserved Domains (1) summary
      PRK09955
      Location:1 → 313
      rihB; ribosylpyrimidine nucleosidase
    Nucleotide Protein
    Heading Accession and Version

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