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    MPD2 protein disulfide isomerase MPD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPD2
    Official Full Name
    protein disulfide isomerase MPD2
    Primary source
    SGD:S000005448
    Locus tag
    YOL088C
    See related
    AllianceGenome:SGD:S000005448; FungiDB:YOL088C; VEuPathDB:YOL088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein disulfide isomerase activity and protein-disulfide reductase activity. Involved in protein folding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPD2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (153912..154745, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mismatch repair ATPase MSH2 Neighboring gene Hal9p Neighboring gene Duf1p Neighboring gene Mhf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Tachikawa H, et al. Biochem Biophys Res Commun, 1997 Oct 29. PMID 9367834
    2. Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Frand AR, et al. Mol Cell, 1999 Oct. PMID 10549279
    3. Functional differences between human and yeast protein disulfide isomerase family proteins. Kimura T, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219835
    4. Functional differences in yeast protein disulfide isomerases. Nørgaard P, et al. J Cell Biol, 2001 Feb 5. PMID 11157982, Free PMC Article
    5. Gene regulation in response to protein disulphide isomerase deficiency. Nørgaard P, et al. Yeast, 2003 May. PMID 12734802

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide isomerase MPD2
    NP_014553.1
    • Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      153912..154745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183342.1 → NP_014553.1  TPA: protein disulfide isomerase MPD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Y0, Q99316
      UniProtKB/TrEMBL
      C7GRU1, G2WME7, N1NX63
      Conserved Domains (1) summary
      cl00388
      Location:48 → 170
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99316.1

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