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    EMC10 Emc10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC10
    Official Full Name
    Emc10p
    Primary source
    SGD:S000002463
    Locus tag
    YDR056C
    See related
    AllianceGenome:SGD:S000002463; FungiDB:YDR056C; VEuPathDB:YDR056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMC10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (565023..565640, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 Neighboring gene Pst1p Neighboring gene Yos9p Neighboring gene triglyceride lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? Wideman JG. F1000Res, 2015. PMID 26512320, Free PMC Article
    2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    3. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
    4. Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. Bloom J, et al. J Biol Chem, 2011 Feb 18. PMID 21127052, Free PMC Article
    5. Chemical-genetic profile analysis of five inhibitory compounds in yeast. Alamgir M, et al. BMC Chem Biol, 2010 Aug 6. PMID 20691087, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emc10p
    NP_010341.3
    • hypothetical protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      565023..565640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180364.3 → NP_010341.3  TPA: Emc10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010341.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS42, Q12025
      UniProtKB/TrEMBL
      B5VFV6, C8Z4X5
      Conserved Domains (1) summary
      cd22209
      Location:21 → 129
      EMC10; ER membrane protein complex subunit 10 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12025.1

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