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    NNF1 MIND complex subunit NNF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NNF1
    Official Full Name
    MIND complex subunit NNF1
    Primary source
    SGD:S000003873
    Locus tag
    YJR112W
    See related
    AllianceGenome:SGD:S000003873; FungiDB:YJR112W; VEuPathDB:YJR112W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation. Located in kinetochore. Part of MIS12/MIND type complex. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to human PMF1-BGLAP (PMF1-BGLAP readthrough) and PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NNF1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (637030..637635)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein RSM7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export. Shan X, et al. J Cell Sci, 1997 Jul. PMID 9247195
    2. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
    3. The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast. Hotz M, et al. Cell Cycle, 2012 Aug 15. PMID 22871738, Free PMC Article
    4. Regulation of mitotic spindle asymmetry by SUMO and the spindle-assembly checkpoint in yeast. Leisner C, et al. Curr Biol, 2008 Aug 26. PMID 18722122
    5. Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Dimitrova YN, et al. Cell, 2016 Nov 3. PMID 27881300, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MIS12/MIND type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MIND complex subunit NNF1
    NP_012646.3
    • Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      637030..637635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181770.3 → NP_012646.3  TPA: MIND complex subunit NNF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012646.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWT1, P47149, Q06779
      UniProtKB/TrEMBL
      A6ZQ68, B3LQJ6, B5VLQ6, C7GM97, C8ZBR0, G2WHB5, N1P3N1
      Conserved Domains (1) summary
      pfam03980
      Location:49 → 155
      Nnf1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47149.3

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