Klra17 killer cell lectin-like receptor, subfamily A, member 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra17provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 17provided by MGI
Primary source: MGI:MGI:2180674
See related: Ensembl:ENSMUSG00000014543 AllianceGenome:MGI:2180674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly49q; Ly49q1
Summary: Enables MHC class I protein binding activity. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129808117..129853635, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129831154..129876672, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
Title: The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
Ly49Q regulates integrin activation and neutrophil recruitment and is required for an adequate immune response in pulmonary infection.
Title: The ITIM Domain-Containing NK Receptor Ly49Q Impacts Pulmonary Infection by Mediating Neutrophil Functions.
This study provides an example in which an ITIM-bearing receptor Ly49Q functions as a positive regulator of osteoclast differentiation.
Title: Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
crucial for the neutrophil polarization and tissue infiltration during inflammation
Title: The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
A novel mechanism by which TLR9 signaling is controlled through the spatiotemporal regulation of membrane trafficking by the immunoreceptor tyrosine-based inhibitory motif-bearing receptor Ly49Q.
Title: Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.
Results show that class I MHC recognition by Ly49Q on plasmacytoid dendritic cells is necessary for optimal activation of innate immune responses in vivo.
Title: Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
Ly49Q serves a role for the biological functions of certain dendritic cell subsets through recognition of MHC class I or related molecules.
Title: Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner.
These results demonstrate that Ly49Q efficiently binds H-2K(b) ligand.
Title: Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.
has unique features different from other known Ly49 family members and appears to be involved in regulation of cytoskeletal architecture of macrophages through ITIM-mediated signaling
Title: Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.
Different expression levels of inhibitory natural killer (NK) receptor Ly49Q define sequential developmental stages of murine plasmacytoid dendritic cells in bone marrow.
Title: Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: killer cell lectin-like receptor, subfamily A, member 17

Names: NK receptor Ly-49Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001381962.1 → NP_001368891.1 killer cell lectin-like receptor, subfamily A, member 17 isoform 1

Status: VALIDATED

Source sequence(s)

AB033769, AC090563

UniProtKB/TrEMBL

Q6DUV0, Q8BJS9

Related

ENSMUSP00000014687.5, ENSMUST00000014687.11

Conserved Domains (2) summary

cd03593
Location:146 → 261

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:41 → 159

Ly49; Ly49-like protein, N-terminal region
NM_133203.5 → NP_573466.3 killer cell lectin-like receptor, subfamily A, member 17 isoform 2

See identical proteins and their annotated locations for NP_573466.3

Status: VALIDATED

Source sequence(s)

AB033769, AK080021

Consensus CDS

CCDS39664.1

UniProtKB/TrEMBL

Q6DUV0, Q9JMA4

Related

ENSMUSP00000114108.3, ENSMUST00000122219.2

Conserved Domains (2) summary

cd03593
Location:145 → 260

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 158

Ly49; Ly49-like protein, N-terminal region