Ccar2 cell cycle activator and apoptosis regulator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccar2provided by MGI
Official Full Name: cell cycle activator and apoptosis regulator 2provided by MGI
Primary source: MGI:MGI:2444228
See related: Ensembl:ENSMUSG00000033712 AllianceGenome:MGI:2444228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dbc1; mKIAA1967; 2610301G19Rik
Summary: Enables enzyme inhibitor activity. Involved in negative regulation of catalytic activity and regulation of circadian rhythm. Located in nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human CCAR2 (cell cycle and apoptosis regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 35.4), whole brain E14.5 (RPKM 35.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.24 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70375617..70391272, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70138168..70153791, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting.
Title: DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting.
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.
Title: SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells.
Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
Title: Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion.
Title: The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion.
A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Title: A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.
Title: An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity.
Dbc1 ablation increases Scd1 levels, causes obesity and insulin resistance.
Title: Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
phosphorylation of DBC1 at its C terminus by IKKalpha facilitates its interaction with RelB and IKKalpha, indicating that DBC1-mediated suppression of alternative NF-kappaB is regulated by IKKalpha.
Title: Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation.
induced the expression of nuclear factor kappa B (NF-kappaB)-regulated inflammatory cytokines in fully differentiated 3T3-L1 adipocytes, possibly through the inhibition of Sirt1 activity
Title: DBC1 is involved in adipocyte inflammation and is a possible marker of human adipose tissue senescence.
We propose that DBC1 is part of the molecular machinery that regulates fat storage capacity in adipocytes and participates in the "turn-off" switch that limits adipocyte fat accumulation.
Title: Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26825-26826:1034282505:1 (e-PCR)
- UniSTS:269089

AU016692 (e-PCR)
- UniSTS:186010

UniSTS:237223 (e-PCR)
- UniSTS:237223

RH143886 (e-PCR)
- UniSTS:233132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fragmentation involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein deacetylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DBIRD complex	ISO Inferred from Sequence Orthology more info
part_of DBIRD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cell cycle and apoptosis regulator protein 2

Names: cell division cycle and apoptosis regulator protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146055.3 → NP_666167.3 cell cycle and apoptosis regulator protein 2

See identical proteins and their annotated locations for NP_666167.3

Status: VALIDATED

Source sequence(s)

AC151836

Consensus CDS

CCDS49534.1

UniProtKB/Swiss-Prot

Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6, Q8VDP4

Related

ENSMUSP00000036924.6, ENSMUST00000035612.7

Conserved Domains (4) summary

COG1196
Location:811 → 917

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK13914
Location:444 → 494

PRK13914; invasion associated endopeptidase

pfam14443
Location:343 → 454

DBC1

pfam14444
Location:55 → 112

S1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70375617..70391272 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518897.5 → XP_006518960.1 cell cycle and apoptosis regulator protein 2 isoform X2

Conserved Domains (4) summary

COG1196
Location:810 → 916

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK13914
Location:444 → 494

PRK13914; invasion associated endopeptidase

pfam14443
Location:343 → 454

DBC1

pfam14444
Location:55 → 112

S1-like
XM_006518896.5 → XP_006518959.1 cell cycle and apoptosis regulator protein 2 isoform X1

See identical proteins and their annotated locations for XP_006518959.1

UniProtKB/Swiss-Prot

Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6, Q8VDP4

Conserved Domains (4) summary

COG1196
Location:811 → 917

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK13914
Location:444 → 494

PRK13914; invasion associated endopeptidase

pfam14443
Location:343 → 454

DBC1

pfam14444
Location:55 → 112

S1-like