Pgls 6-phosphogluconolactonase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pglsprovided by MGI
Official Full Name: 6-phosphogluconolactonaseprovided by MGI
Primary source: MGI:MGI:1913421
See related: Ensembl:ENSMUSG00000031807 AllianceGenome:MGI:1913421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plgs; 1110030K05Rik
Summary: Predicted to enable 6-phosphogluconolactonase activity and monosaccharide binding activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in cerebellum; hemolymphoid system; and thymus primordium. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 208.2), ovary adult (RPKM 111.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72044828..72048911)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71592184..71596267)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hub gene underlying brain aging
Title: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI447866 (e-PCR)
- UniSTS:159774

Pgls (e-PCR), detects polymorphism
- UniSTS:498788

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphogluconolactonase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 6-phosphogluconolactonase

Names: 6PGL

NP_001281198.1

EC 3.1.1.31

NP_079672.1

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001294269.1 → NP_001281198.1 6-phosphogluconolactonase isoform 2

See identical proteins and their annotated locations for NP_001281198.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC162033, AK003134, AK003985, BE654173

Consensus CDS

CCDS80895.1

UniProtKB/TrEMBL

D3Z4X1

Related

ENSMUSP00000116524.2, ENSMUST00000143441.2

Conserved Domains (1) summary

cd01400
Location:15 → 156

6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...
NM_025396.3 → NP_079672.1 6-phosphogluconolactonase isoform 1

See identical proteins and their annotated locations for NP_079672.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC162033

Consensus CDS

CCDS22400.1

UniProtKB/Swiss-Prot

Q3TA62, Q9CQ60

UniProtKB/TrEMBL

Q8CBG6

Related

ENSMUSP00000034264.5, ENSMUST00000034264.11

Conserved Domains (1) summary

TIGR01198
Location:11 → 247

pgl; 6-phosphogluconolactonase