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    MUP1 Mup1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MUP1
    Official Full Name
    Mup1p
    Primary source
    SGD:S000003287
    Locus tag
    YGR055W
    See related
    AllianceGenome:SGD:S000003287; FungiDB:YGR055W; VEuPathDB:YGR055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-methionine secondary active transmembrane transporter activity. Involved in methionine import across plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria; gastrointestinal system cancer (multiple); lung squamous cell carcinoma; and lysinuric protein intolerance. Orthologous to several human genes including SLC7A10 (solute carrier family 7 member 10); SLC7A11 (solute carrier family 7 member 11); and SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MUP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (599417..601141)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mco32p Neighboring gene translation initiation factor 2A Neighboring gene RSC subunit protein RSC1 Neighboring gene Lst7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MUP1, high affinity methionine permease, is involved in cysteine uptake by Saccharomyces cerevisiae. Kosugi A, et al. Biosci Biotechnol Biochem, 2001 Mar. PMID 11330701
    2. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Matlack KE, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591589, Free PMC Article
    3. Mutation of high-affinity methionine permease contributes to selenomethionyl protein production in Saccharomyces cerevisiae. Kitajima T, et al. Appl Environ Microbiol, 2010 Oct. PMID 20693451, Free PMC Article
    4. Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast. Prosser DC, et al. J Vis Exp, 2016 Oct 23. PMID 27805610, Free PMC Article
    5. The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases. Isnard AD, et al. J Mol Biol, 1996 Oct 4. PMID 8893857

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in methionine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur amino acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mup1p
    NP_011569.1
    • High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      599417..601141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181184.1 → NP_011569.1  TPA: Mup1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011569.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ0, P50276, Q45U31
      UniProtKB/TrEMBL
      A6ZV40, B3LIG8, B5VJ05, C7GXN8, C8Z8U9, G2WEE2, N1P3H8
      Conserved Domains (1) summary
      TIGR00911
      Location:1 → 541
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50276.1

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