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    NUF2 kinetochore-associated Ndc80 complex subunit NUF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUF2
    Official Full Name
    kinetochore-associated Ndc80 complex subunit NUF2
    Primary source
    SGD:S000005430
    Locus tag
    YOL069W
    See related
    AllianceGenome:SGD:S000005430; FungiDB:YOL069W; VEuPathDB:YOL069W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; spindle microtubule; and spindle pole body. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUF2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (198942..200297)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase assembly factor SDH5 Neighboring gene Nba1p Neighboring gene histone deacetylase HST1 Neighboring gene Rtg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. Osborne MA, et al. J Cell Biol, 1994 May. PMID 8188751, Free PMC Article
    2. Coupling unbiased mutagenesis to high-throughput DNA sequencing uncovers functional domains in the Ndc80 kinetochore protein of Saccharomyces cerevisiae. Tien JF, et al. Genetics, 2013 Sep. PMID 23833183, Free PMC Article
    3. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
    4. Microtubule dynamics from mating through the first zygotic division in the budding yeast Saccharomyces cerevisiae. Maddox P, et al. J Cell Biol, 1999 Mar 8. PMID 10085295, Free PMC Article
    5. The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Maure JF, et al. Curr Biol, 2011 Feb 8. PMID 21256019, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
      Title: Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in kinetochore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ndc80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinetochore-associated Ndc80 complex subunit NUF2
    NP_014572.1
    • Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      198942..200297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183324.1 → NP_014572.1  TPA: kinetochore-associated Ndc80 complex subunit NUF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014572.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Z8, P33895, Q6B1X5
      UniProtKB/TrEMBL
      A6ZNE1, B5VRI3, C7GK36, G2WMG5, N1NWD5
      Conserved Domains (2) summary
      COG1196
      Location:182 → 421
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03800
      Location:5 → 148
      Nuf2; Nuf2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33895.1

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