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    Ero1b endoplasmic reticulum oxidoreductase 1 beta [ Mus musculus (house mouse) ]

    Gene ID: 67475, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ero1bprovided by MGI
    Official Full Name
    endoplasmic reticulum oxidoreductase 1 betaprovided by MGI
    Primary source
    MGI:MGI:1914725
    See related
    Ensembl:ENSMUSG00000057069 AllianceGenome:MGI:1914725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ero1lb; ero1-beta; 1300013B24Rik; 1700065B09Rik
    Summary
    Enables protein-disulfide reductase activity. Involved in insulin processing. Acts upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in membrane. Is active in endoplasmic reticulum lumen. Is expressed in heart and hindlimb joint. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 15.0), spleen adult (RPKM 5.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ero1b in Genome Data Viewer
    Location:
    13 A1; 13 5.07 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12580701..12624422)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12565818..12609533)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene EDAR associated via death domain Neighboring gene VISTA enhancer mm1376 Neighboring gene predicted gene, 30239 Neighboring gene STARR-positive B cell enhancer ABC_E4051 Neighboring gene STARR-positive B cell enhancer ABC_E1455 Neighboring gene predicted gene, 25483 Neighboring gene G protein-coupled receptor 137B, pseudogene Neighboring gene nidogen-1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Clone Names

    • MGC77955

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables disulfide oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ERO1-like protein beta
    Names
    ERO1-L-beta
    ERO1-like beta
    endoplasmic oxidoreductase 1 beta
    endoplasmic oxidoreductin-1-like protein B
    endoplasmic reticulum oxidoreductase beta
    endoplasmic reticulum oxidoreductin-1-like protein B
    oxidoreductin-1-L-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418471.1NP_001405400.1  ERO1-like protein beta isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT954220
      UniProtKB/TrEMBL
      A0A1Y7VNF4, Q14DR9
      Related
      ENSMUSP00000152393.2, ENSMUST00000221560.2
    2. NM_001418478.1NP_001405407.1  ERO1-like protein beta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CT954220
      UniProtKB/TrEMBL
      Q14DR9
    3. NM_001418479.1NP_001405408.1  ERO1-like protein beta isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      CT954220
      UniProtKB/TrEMBL
      Q14DR9
    4. NM_001418481.1NP_001405410.1  ERO1-like protein beta isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      CT954220
    5. NM_026184.3NP_080460.2  ERO1-like protein beta isoform 2 precursor

      See identical proteins and their annotated locations for NP_080460.2

      Status: VALIDATED

      Source sequence(s)
      CT954220
      Consensus CDS
      CCDS36594.1
      UniProtKB/Swiss-Prot
      Q14DN0, Q8R2E9
      UniProtKB/TrEMBL
      Q14DR9
      Related
      ENSMUSP00000071864.7, ENSMUST00000071973.8
      Conserved Domains (1) summary
      pfam04137
      Location:56454
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      12580701..12624422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516731.5XP_006516794.1  ERO1-like protein beta isoform X2

      UniProtKB/TrEMBL
      Q14DR9
      Conserved Domains (1) summary
      pfam04137
      Location:56454
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
    2. XM_006516732.4XP_006516795.1  ERO1-like protein beta isoform X3

      UniProtKB/TrEMBL
      Q14DR9
      Related
      ENSMUSP00000152543.2, ENSMUST00000220811.2
      Conserved Domains (1) summary
      pfam04137
      Location:56448
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)