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    Nckap5l NCK-associated protein 5-like [ Mus musculus (house mouse) ]

    Gene ID: 380969, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nckap5lprovided by MGI
    Official Full Name
    NCK-associated protein 5-likeprovided by MGI
    Primary source
    MGI:MGI:3609653
    See related
    Ensembl:ENSMUSG00000023009 AllianceGenome:MGI:3609653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cep169; C230021P08Rik
    Summary
    Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be located in centrosome. Predicted to be active in microtubule plus-end. Is expressed in central nervous system and retina. Orthologous to human NCKAP5L (NCK associated protein 5 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 18.9), thymus adult (RPKM 16.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nckap5l in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99319915..99355676, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99422034..99457938, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene formin-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E761 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5516 Neighboring gene BCDIN3 domain containing Neighboring gene Fas apoptotic inhibitory molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
    2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nck-associated protein 5-like
    Names
    centrosomal protein of 169 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001884.2 → NP_001001884.1  nck-associated protein 5-like

      See identical proteins and their annotated locations for NP_001001884.1

      Status: VALIDATED

      Source sequence(s)
      AC117831, AC118646
      Consensus CDS
      CCDS27820.1
      UniProtKB/Swiss-Prot
      Q6GQX2, Q8BX75, Q8R364
      Related
      ENSMUSP00000023747.8, ENSMUST00000023747.14
      Conserved Domains (3) summary
      PHA03247
      Location:418 → 876
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:210 → 529
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:871 → 1171
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. NM_001403554.1 → NP_001390483.1  nck-associated protein 5-like

      Status: VALIDATED

      Source sequence(s)
      AC117831, AC118646
      UniProtKB/Swiss-Prot
      Q6GQX2, Q8BX75, Q8R364

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99319915..99355676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521122.5 → XP_006521185.1  nck-associated protein 5-like isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:446 → 904
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:238 → 557
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam07926
      Location:55 → 131
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam15246
      Location:899 → 1199
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. XM_036159478.1 → XP_036015371.1  nck-associated protein 5-like isoform X2

      UniProtKB/Swiss-Prot
      Q6GQX2, Q8BX75, Q8R364
      Conserved Domains (3) summary
      PHA03247
      Location:418 → 876
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:210 → 529
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:871 → 1171
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    3. XM_036159477.1 → XP_036015370.1  nck-associated protein 5-like isoform X2

      UniProtKB/Swiss-Prot
      Q6GQX2, Q8BX75, Q8R364
      Conserved Domains (3) summary
      PHA03247
      Location:418 → 876
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:210 → 529
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:871 → 1171
      NCKAP5; Nck-associated protein 5, Peripheral clock protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQX2.1 GenPept UniProtKB/Swiss-Prot:Q6GQX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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