U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slamf6 SLAM family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 30925, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slamf6provided by MGI
    Official Full Name
    SLAM family member 6provided by MGI
    Primary source
    MGI:MGI:1353620
    See related
    Ensembl:ENSMUSG00000015314 AllianceGenome:MGI:1353620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAL1; NTBA; KAL1b; Ly108; NTB-A; SF2000
    Summary
    Involved in natural killer cell differentiation and natural killer cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF6 (SLAM family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 3.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slamf6 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171745002..171776525)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171917458..171948958)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD84 antigen Neighboring gene predicted gene, 51686 Neighboring gene STARR-seq mESC enhancer starr_03042 Neighboring gene STARR-seq mESC enhancer starr_03043 Neighboring gene STARR-seq mESC enhancer starr_03044 Neighboring gene predicted gene 52845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:173849407-173849647 Neighboring gene STARR-positive B cell enhancer ABC_E3330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:173851483-173851687 Neighboring gene predicted gene, 37065 Neighboring gene STARR-seq mESC enhancer starr_03046 Neighboring gene STARR-positive B cell enhancer ABC_E5850 Neighboring gene VISTA enhancer mm1677 Neighboring gene VANGL planar cell polarity 2 Neighboring gene STARR-positive B cell enhancer ABC_E9498 Neighboring gene nescient helix loop helix 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in natural killer cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    SLAM family member 6
    Names
    lymphocyte antigen 108

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347186.1NP_001334115.1  SLAM family member 6 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC091523, BC030031
      Consensus CDS
      CCDS83638.1
      UniProtKB/Swiss-Prot
      C6ESQ1, Q9ET39, Q9ET40
      UniProtKB/TrEMBL
      Q18PJ0, Q18PJ2
      Related
      ENSMUSP00000141448.2, ENSMUST00000195656.6
    2. NM_001347187.1NP_001334116.1  SLAM family member 6 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC091523, EU591721
      Consensus CDS
      CCDS83639.1
      UniProtKB/TrEMBL
      Q18PJ2
      Related
      ENSMUSP00000141944.2, ENSMUST00000194561.2
    3. NM_030710.3NP_109635.1  SLAM family member 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_109635.1

      Status: VALIDATED

      Source sequence(s)
      AC091523
      Consensus CDS
      CCDS15504.1
      UniProtKB/TrEMBL
      Q18PG5, Q18PJ2
      Related
      ENSMUSP00000130610.2, ENSMUST00000171330.7
      Conserved Domains (1) summary
      cl11960
      Location:44142
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171745002..171776525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496884.5XP_006496947.1  SLAM family member 6 isoform X1

      UniProtKB/TrEMBL
      Q18PJ2
      Conserved Domains (1) summary
      cl11960
      Location:44142
      Ig; Immunoglobulin domain
    2. XM_006496886.5XP_006496949.1  SLAM family member 6 isoform X2

      UniProtKB/TrEMBL
      Q18PJ2
      Conserved Domains (1) summary
      cl11960
      Location:25123
      Ig; Immunoglobulin domain
    3. XM_011238825.3XP_011237127.1  SLAM family member 6 isoform X3

    RNA

    1. XR_373611.5 RNA Sequence