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    MTR2 Mtr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTR2
    Official Full Name
    Mtr2p
    Primary source
    SGD:S000001669
    Locus tag
    YKL186C
    See related
    AllianceGenome:SGD:S000001669; FungiDB:YKL186C; VEuPathDB:YKL186C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nuclear export and tRNA processing. Part of nuclear RNA export factor complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MTR2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (92744..93298, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette long-chain fatty acid transporter PXA2 Neighboring gene Fat3p Neighboring gene DNA-binding transcription repressor ASH1 Neighboring gene ornithine decarboxylase SPE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. Kadowaki T, et al. Mol Biol Cell, 1994 Nov. PMID 7865887, Free PMC Article
    2. Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene. Wiemann S, et al. Yeast, 1993 Dec. PMID 8154185
    3. Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2. Yao W, et al. Mol Cell, 2007 Apr 13. PMID 17434126
    4. RNA secondary structure mediates alternative 3'ss selection in Saccharomyces cerevisiae. Plass M, et al. RNA, 2012 Jun. PMID 22539526, Free PMC Article
    5. Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface. Aibara S, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25618852, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mex67-Mtr2 functions in primary nuclear export for a subset of yeast tRNAs
      Title: Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.
    2. This study describes the mechanism of recruitment of the Saccharomyces cerevisiae RNA-export receptor Mex67-Mtr2 to the pre-60S subunit at the proper time. Mex67-Mtr2 binds at the premature ribosomal-stalk region, which later during translation serves as a binding platform for translational GTPases on the mature ribosome.
      Title: Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.
    3. show that the NTF2-like domain from Saccharomyces cerevisiae Mex67:Mtr2 also contributes to RNA binding
      Title: Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.
    4. Thus Mex67-Mtr2 is a unique transport receptor that employs a common interaction surface to participate in the nuclear export of both pre-ribosomal subunits and mRNAs
      Title: Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.
    5. Mex67-Mtr2 export receptor employs a versatile binding platform on its surface that can create a crosstalk between mRNA and ribosome export pathways.
      Title: A versatile interaction platform on the Mex67-Mtr2 receptor creates an overlap between mRNA and ribosome export.
    6. Thus, the general mRNA exporter Mex67-Mtr2 contains a distinct electrostatic interaction surface for transporting 60S preribosomal cargo.
      Title: Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear RNA export factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtr2p
    NP_012735.1
    • mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      92744..93298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179752.1 → NP_012735.1  TPA: Mtr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012735.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX14, P34232
      UniProtKB/TrEMBL
      A6ZZD9, B3LQR9, C7GJ23, C8ZBZ0, G2WHK6, N1NZM2
      Conserved Domains (1) summary
      pfam10429
      Location:13 → 184
      Mtr2; Nuclear pore RNA shuttling protein Mtr2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34232.1

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