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    Snx9 sorting nexin 9 [ Mus musculus (house mouse) ]

    Gene ID: 66616, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx9provided by MGI
    Official Full Name
    sorting nexin 9provided by MGI
    Primary source
    MGI:MGI:1913866
    See related
    Ensembl:ENSMUSG00000002365 AllianceGenome:MGI:1913866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDP1; SH3PX1; 2700073N08Rik
    Summary
    Enables phosphatidylinositol binding activity. Involved in positive regulation of actin filament polymerization. Acts upstream of or within intracellular protein transport. Located in cytoplasm and plasma membrane. Colocalizes with cuticular plate. Is expressed in lower jaw molar and upper jaw molar. Orthologous to human SNX9 (sorting nexin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 37.0), large intestine adult (RPKM 23.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Snx9 in Genome Data Viewer
    Location:
    17 A1; 17 3.51 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (5891599..5982231)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (5841324..5931956)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3300005D01 gene Neighboring gene STARR-positive B cell enhancer ABC_E10931 Neighboring gene STARR-positive B cell enhancer ABC_E10932 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) pseudogene Neighboring gene predicted gene, 35474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5885599-5885708 Neighboring gene STARR-positive B cell enhancer mm9_chr17:5934164-5934465 Neighboring gene STARR-positive B cell enhancer mm9_chr17:5934996-5935297 Neighboring gene STARR-seq mESC enhancer starr_41704 Neighboring gene predicted gene, 46599 Neighboring gene STARR-seq mESC enhancer starr_41705 Neighboring gene mRNA turnover 4 pseudogene Neighboring gene synaptojanin 2 Neighboring gene STARR-seq mESC enhancer starr_41707 Neighboring gene predicted gene, 52312

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cleavage furrow formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid tube assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid tube assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane tubulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cuticular plate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025664.6NP_079940.2  sorting nexin-9

      See identical proteins and their annotated locations for NP_079940.2

      Status: VALIDATED

      Source sequence(s)
      AC168063, AK155830
      Consensus CDS
      CCDS57041.1
      UniProtKB/Swiss-Prot
      Q91VH2
      UniProtKB/TrEMBL
      Q3TZU7, Q3U1P2
      Related
      ENSMUSP00000002436.10, ENSMUST00000002436.11
      Conserved Domains (3) summary
      cd07285
      Location:250375
      PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
      cd07668
      Location:386595
      BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
      cd11898
      Location:460
      SH3_SNX9; Src Homology 3 domain of Sorting nexin 9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      5891599..5982231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317612.3XP_017173101.1  sorting nexin-9 isoform X1

      UniProtKB/TrEMBL
      Q3TZU7
      Conserved Domains (4) summary
      cd07285
      Location:250375
      PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
      cd07668
      Location:386595
      BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
      cd11898
      Location:560
      SH3_SNX9; Src Homology 3 domain of Sorting nexin 9
      COG5391
      Location:127357
      COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
    2. XM_030249990.2XP_030105850.1  sorting nexin-9 isoform X2

      UniProtKB/TrEMBL
      Q9CZK0
      Conserved Domains (2) summary
      cd07285
      Location:50175
      PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
      cd07668
      Location:186395
      BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9