TSR3 ribosome biogenesis protein TSR3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TSR3
Official Full Name: ribosome biogenesis protein TSR3
Primary source: SGD:S000005532
Locus tag: YOR006C
See related: AllianceGenome:SGD:S000005532; FungiDB:YOR006C; VEuPathDB:YOR006C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 18S rRNA aminocarboxypropyltransferase activity. Involved in maturation of SSU-rRNA. Located in peroxisome. Orthologous to human TSR3 (TSR3 ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Structurally, Tsr3 represents a novel class of acp transferase enzymes.
Title: Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 18S rRNA aminocarboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 18S rRNA aminocarboxypropyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables S-adenosyl-L-methionine binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in enzyme-directed rRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_014648.1

Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes

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The following sections contain reference sequences that belong to a specific genome build. Explain