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    MGL2 putative carboxylic ester hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MGL2
    Official Full Name
    putative carboxylic ester hydrolase
    Primary source
    SGD:S000004823
    Locus tag
    YMR210W
    See related
    AllianceGenome:SGD:S000004823; FungiDB:YMR210W; VEuPathDB:YMR210W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables monoacylglycerol lipase activity and triacylglycerol lipase activity. Involved in medium-chain fatty acid biosynthetic process and triglyceride metabolic process. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MGL2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (687516..688865)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mevalonate kinase Neighboring gene uncharacterized protein Neighboring gene Dml1p Neighboring gene Efr3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ymr210wp leads to the accumulation of phospholipids and steryl esters in yeast. Manda NK, et al. Bioinformation, 2017. PMID 29225428, Free PMC Article
    2. MGL2/YMR210w encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. Selvaraju K, et al. FEBS Lett, 2016 Apr. PMID 26991558
    3. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. Saerens SM, et al. J Biol Chem, 2006 Feb 17. PMID 16361250
    4. Metabolic, Organoleptic and Transcriptomic Impact of Saccharomyces cerevisiae Genes Involved in the Biosynthesis of Linear and Substituted Esters. Marullo P, et al. Int J Mol Sci, 2021 Apr 14. PMID 33919724, Free PMC Article
    5. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative carboxylic ester hydrolase
    NP_013937.1
    • Monoacylglycerol and triacylglycerol lipase; MAG lipase with preference for palmitoyl-MAG; TAG lipase involved in TAG catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif (GXSXG); similar to acyltransferases, Eeb1p, Eht1p, and human ABHD1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      687516..688865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182717.1 → NP_013937.1  TPA: putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W035, Q03649
      UniProtKB/TrEMBL
      A6ZMS2, B3LM98, C7GRE1, C8ZF74, N1NYL9
      Conserved Domains (1) summary
      COG0429
      Location:33 → 433
      YheT; Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03649.1

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