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    MNN10 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNN10
    Official Full Name
    alpha-1,6-mannosyltransferase
    Primary source
    SGD:S000002653
    Locus tag
    YDR245W
    See related
    AllianceGenome:SGD:S000002653; FungiDB:YDR245W; VEuPathDB:YDR245W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BED1; REC41; SLC2
    Summary
    Enables alpha-1,6-mannosyltransferase activity. Involved in cell wall mannoprotein biosynthetic process; division septum assembly; and protein N-linked glycosylation. Located in endoplasmic reticulum. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNN10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (952800..953981)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein PRP28 Neighboring gene Pex5p Neighboring gene TRAPP subunit TRS23 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Rec41--a new gene, participating in the control of recombination in Saccharomyces cerevisiae yeast]. Chepurnaia OV, et al. Genetika, 1993 Feb. PMID 8486254
    2. BED1, a gene encoding a galactosyltransferase homologue, is required for polarized growth and efficient bud emergence in Saccharomyces cerevisiae. Mondésert G, et al. J Cell Biol, 1996 Jan. PMID 8567719, Free PMC Article
    3. Molecular and phenotypic analysis of the S. cerevisiae MNN10 gene identifies a family of related glycosyltransferases. Dean N, et al. Glycobiology, 1996 Jan. PMID 8991513
    4. Protein glycosylation defects in the Saccharomyces cerevisiae mnn7 mutant class. Support for the stop signal proposed for regulation of outer chain elongation. Ballou L, et al. J Biol Chem, 1989 Jul 15. PMID 2663843
    5. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Schmidt M, et al. Yeast, 2005 Jul 15. PMID 16034811

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosyltransferase
    NP_010531.1
    • Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      952800..953981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180553.1 → NP_010531.1  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSM5, P50108
      UniProtKB/TrEMBL
      A6ZYJ7, B3LG44, B5VGD1, C7GTI0, C8Z5F6, G2WAY8, N1P6Y1
      Conserved Domains (1) summary
      pfam05637
      Location:118 → 368
      Glyco_transf_34; galactosyl transferase GMA12/MNN10 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50108.1

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