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    FAR11 Far11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FAR11
    Official Full Name
    Far11p
    Primary source
    SGD:S000005071
    Locus tag
    YNL127W
    See related
    AllianceGenome:SGD:S000005071; FungiDB:YNL127W; VEuPathDB:YNL127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitotic intra-S DNA damage checkpoint signaling; positive regulation of macroautophagy; and re-entry into mitotic cell cycle after pheromone arrest. Located in Golgi trans cisterna and endoplasmic reticulum. Orthologous to human STRIP1 (striatin interacting protein 1) and STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FAR11 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (383987..386848)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosylnicotinamide kinase Neighboring gene putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Neighboring gene Spc98p Neighboring gene Esbp6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ham-2 locus, encoding a putative transmembrane protein, is required for hyphal fusion in Neurospora crassa. Xiang Q, et al. Genetics, 2002 Jan. PMID 11805054, Free PMC Article
    2. Mitophagy regulation mediated by the Far complex in yeast. Furukawa K, et al. Autophagy, 2021 Apr. PMID 33530805, Free PMC Article
    3. The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion. Niphadkar S, et al. PLoS Genet, 2024 Mar. PMID 38452140, Free PMC Article
    4. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
    5. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Far3, Far7, and Far8 form a subcomplex, which is recruited to the ER by Far9/10. The Far3-7-8- complex in turn recruits Far11 to the ER.
      Title: Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum.
    2. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.
      Title: The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Far11p
    NP_014272.3
    • Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      383987..386848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182965.3 → NP_014272.3  TPA: Far11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014272.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W156, P53917
      UniProtKB/TrEMBL
      A6ZRV7, B3LNY3, N1NXV4
      Conserved Domains (2) summary
      pfam07923
      Location:219 → 485
      N1221; N1221-like protein
      pfam11882
      Location:585 → 928
      DUF3402; Domain of unknown function (DUF3402)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53917.1

    Gene LinkOut

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