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    Thap7 THAP domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 69009, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Thap7provided by MGI
    Official Full Name
    THAP domain containing 7provided by MGI
    Primary source
    MGI:MGI:1916259
    See related
    Ensembl:ENSMUSG00000022760 AllianceGenome:MGI:1916259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810004B07Rik
    Summary
    Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nuclear membrane; and nuclear speck. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; heart; reproductive system; and urinary system. Orthologous to human THAP7 (THAP domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in ovary adult (RPKM 39.8), adrenal adult (RPKM 37.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thap7 in Genome Data Viewer
    Location:
    16 A3; 16 10.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17345823..17349975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17527959..17531151, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3 Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
    2. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
    3. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables general transcription initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    THAP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026909.2 → NP_081185.1  THAP domain-containing protein 7

      Status: PROVISIONAL

      Source sequence(s)
      AC113006
      Consensus CDS
      CCDS28004.1
      UniProtKB/Swiss-Prot
      Q8VCZ3
      UniProtKB/TrEMBL
      Q3U3Q2
      Related
      ENSMUSP00000097701.4, ENSMUST00000100125.12
      Conserved Domains (2) summary
      smart00980
      Location:4 → 93
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
      PHA03247
      Location:111 → 221
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17345823..17349975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246003.4 → XP_011244305.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A338P7J4

    2. XM_006522513.5 → XP_006522576.1  THAP domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      Q3U3Q2
      Conserved Domains (1) summary
      PHA03247
      Location:59 → 169
      PHA03247; large tegument protein UL36; Provisional

    3. XM_030249261.2 → XP_030105121.1  THAP domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      Q3U3Q2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 74
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    4. XM_036160107.1 → XP_036016000.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A338P7J4
      Related
      ENSMUSP00000156319.2, ENSMUST00000232041.2

    5. XM_006522511.5 → XP_006522574.1  THAP domain-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCZ3
      UniProtKB/TrEMBL
      Q3U3Q2
      Related
      ENSMUSP00000156168.2, ENSMUST00000231548.2
      Conserved Domains (2) summary
      smart00980
      Location:4 → 93
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
      PHA03247
      Location:111 → 221
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCZ3.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ3

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