AMS1 alpha-mannosidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AMS1
Official Full Name: alpha-mannosidase
Primary source: SGD:S000003124
Locus tag: YGL156W
See related: AllianceGenome:SGD:S000003124; FungiDB:YGL156W; VEuPathDB:YGL156W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables alpha-mannosidase activity. Involved in carbohydrate catabolic process; cellular response to glucose starvation; and cellular response to nitrogen starvation. Located in fungal-type vacuole membrane. Part of Cvt complex. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 2. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AMS1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (210416..213667)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
Title: Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
Atg34p and Atg19p have similar domain structures and are important for Ams1p transport during autophagy.
Title: Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
Title: Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
AMS1 of Saccharomyces cerevisiae, a cargo protein of the Cvt pathway, was crystallized.
Title: Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cvt complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-mannosidase

NP_011359.1

EC 3.2.1.24

Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

210416..213667

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181021.1 → NP_011359.1 TPA: alpha-mannosidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011359.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTZ5, P22855

UniProtKB/TrEMBL

N1P6H0

Conserved Domains (1) summary

COG0383
Location:44 → 1083

AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]