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    Erp27 endoplasmic reticulum protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 69187, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Erp27provided by MGI
    Official Full Name
    endoplasmic reticulum protein 27provided by MGI
    Primary source
    MGI:MGI:1916437
    See related
    Ensembl:ENSMUSG00000030219 AllianceGenome:MGI:1916437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810033M07Rik; 1810047B09Rik
    Summary
    Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in diencephalon lateral wall mantle layer and midbrain mantle layer. Orthologous to human ERP27 (endoplasmic reticulum protein 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 3.3), small intestine adult (RPKM 2.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Erp27 in Genome Data Viewer
    Location:
    6 G1; 6 66.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136884312..136899465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136907314..136922461, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 4 Neighboring gene matrix Gla protein Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene Rho, GDP dissociation inhibitor beta Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129514, MGC129515

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum resident protein 27
    Names
    ER protein 27
    endoplasmic reticulum resident protein ERp27
    inactive protein disulfide-isomerase 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417693.1 → NP_001404622.1  endoplasmic reticulum resident protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122804, AC125341
      UniProtKB/TrEMBL
      Q9D8Q5
      Related
      ENSMUST00000162243.8

    2. NM_026983.2 → NP_081259.1  endoplasmic reticulum resident protein 27 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK007684
      Consensus CDS
      CCDS20660.1
      UniProtKB/Swiss-Prot
      Q3SX97, Q9D8U3
      Related
      ENSMUSP00000032343.7, ENSMUST00000032343.7
      Conserved Domains (1) summary
      pfam13848
      Location:64 → 250
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136884312..136899465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506554.3 → XP_006506617.1  endoplasmic reticulum resident protein 27 isoform X1

      Conserved Domains (1) summary
      pfam13848
      Location:1 → 174
      Thioredoxin_6; Thioredoxin-like domain

    2. XM_006506555.4 → XP_006506618.1  endoplasmic reticulum resident protein 27 isoform X1

      Conserved Domains (1) summary
      pfam13848
      Location:1 → 174
      Thioredoxin_6; Thioredoxin-like domain

    3. XM_036152285.1 → XP_036008178.1  endoplasmic reticulum resident protein 27 isoform X1

      Conserved Domains (1) summary
      pfam13848
      Location:1 → 174
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8U3.1 GenPept UniProtKB/Swiss-Prot:Q9D8U3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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