U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CTK2 Ctk2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853450, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CTK2
    Official Full Name
    Ctk2p
    Primary source
    SGD:S000003543
    Locus tag
    YJL006C
    See related
    AllianceGenome:SGD:S000003543; FungiDB:YJL006C; VEuPathDB:YJL006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of DNA-templated transcription, elongation; positive regulation of transcription by RNA polymerase I; and positive regulation of translational fidelity. Located in cytosol; nucleolus; and nucleoplasm. Part of CTDK-1 complex. Orthologous to human CCNT1 (cyclin T1) and CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CTK2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (423138..424109, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT8 Neighboring gene uncharacterized protein Neighboring gene tRNA-Met Neighboring gene tRNA-Leu Neighboring gene adenylate cyclase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway. Hautbergue G, et al. Mol Cell Biol, 1999 Apr. PMID 10082518, Free PMC Article
    2. The cyclin family of budding yeast: abundant use of a good idea. Andrews B, et al. Trends Genet, 1998 Feb. PMID 9520600
    3. Expression, purification and crystallization of the complex of RNA polymerase II carboxyl-terminal repeat domain kinase subunits CTK2-CTK3 from Saccharomyces cerevisiae. Zhu W, et al. Protein Expr Purif, 2019 Feb. PMID 30240633
    4. The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Sterner DE, et al. Mol Cell Biol, 1995 Oct. PMID 7565723, Free PMC Article
    5. Budding yeast CTDK-I is required for DNA damage-induced transcription. Ostapenko D, et al. Eukaryot Cell, 2003 Apr. PMID 12684377, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
      Title: Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational fidelity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CTDK-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ctk2p
    NP_012528.1
    • Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      423138..424109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181440.1 → NP_012528.1  TPA: Ctk2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWG9, P46962
      UniProtKB/TrEMBL
      B3LQ93, C7GV40, C8ZBK5, G2WH04, N1P0Z2
      Conserved Domains (1) summary
      COG5333
      Location:1 → 299
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46962.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous