Nrep neuronal regeneration related protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrepprovided by MGI
Official Full Name: neuronal regeneration related proteinprovided by MGI
Primary source: MGI:MGI:99444
See related: Ensembl:ENSMUSG00000042834 AllianceGenome:MGI:99444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Harp; P311; PTZ17; SEZ17; D0H4S114
Summary: Acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including lung; nervous system; otocyst; and retina. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 316.2), whole brain E14.5 (RPKM 274.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.18 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (33570072..33597444, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (33437019..33464365, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P311 regulates distal lung development via its interaction with several binding proteins.
Title: P311 regulates distal lung development via its interaction with several binding proteins.
Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-beta1 pathway.
Title: Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-β1 pathway.
Neuronal regeneration related protein (P311) overexpression enhanced adipogenic differentiation of 3T3-L1 cells.
Title: P311, a novel intrinsically disordered protein, regulates adipocyte development.
The essential function of P311 in TGF-beta-mediated lung fibrosis.P311 regulates TGF-beta1, TGF-beta2 and TGF-beta3 translation in the lung fibrosis.
Title: P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.
P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
Title: P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression.
P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.
Title: P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation.
These studies demonstrate that P311 is required for the production of normal cutaneous scars
Title: Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation.
P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis.
Title: P311 promotes renal fibrosis via TGFβ1/Smad signaling.
P311 is central to reactive oxygen species-mediated hepatic stellate cell migration induced by different chemokines.
Title: P311 modulates hepatic stellate cells migration.
P311 is the first protein identified to modulate TGF-beta translation and the first pan-regulator of TGF-beta expression.
Title: Blood pressure homeostasis is maintained by a P311-TGF-β axis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC151607P1 (e-PCR)
- UniSTS:271151

G54138 (e-PCR)
- UniSTS:109375

D0H4S114 (e-PCR), detects polymorphism
- UniSTS:546731

AI325076 (e-PCR)
- UniSTS:166088

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuronal regeneration-related protein

Names: high-altitude regulated protein; neuronal protein 3.1; protein p311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109988.1 → NP_001103458.1 neuronal regeneration-related protein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC115117, AK020629

Consensus CDS

CCDS37756.1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Related

ENSMUSP00000130297.2, ENSMUST00000168890.2

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)
NM_001109989.2 → NP_001103459.1 neuronal regeneration-related protein

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC115117, CX768079

Consensus CDS

CCDS37756.1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Related

ENSMUSP00000157912.2, ENSMUST00000237066.2

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)
NM_001267717.1 → NP_001254646.1 neuronal regeneration-related protein

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC115117

Consensus CDS

CCDS37756.1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)
NM_053078.4 → NP_444308.1 neuronal regeneration-related protein

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AK048361, AV321356, CJ148521

Consensus CDS

CCDS37756.1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Related

ENSMUSP00000058132.9, ENSMUST00000051087.16

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

33570072..33597444 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250488.2 → XP_030106348.1 neuronal regeneration-related protein isoform X1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)
XM_036161164.1 → XP_036017057.1 neuronal regeneration-related protein isoform X1

UniProtKB/Swiss-Prot

Q07475

UniProtKB/TrEMBL

Q542Q5

Conserved Domains (1) summary

pfam11092
Location:3 → 68

Alveol-reg_P311; Neuronal protein 3.1 (p311)