Rnf138 ring finger protein 138 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf138provided by MGI
Official Full Name: ring finger protein 138provided by MGI
Primary source: MGI:MGI:1929211
See related: Ensembl:ENSMUSG00000024317 AllianceGenome:MGI:1929211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trif; STRIN; Trif-d; 2410015A17Rik; 2810480D20Rik
Summary: Predicted to enable protein kinase binding activity; single-stranded DNA binding activity; and ubiquitin protein ligase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in site of double-strand break. Is expressed in several structures, including genitourinary system; lung; nervous system; sensory organ; and tooth. Orthologous to human RNF138 (ring finger protein 138). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in testis adult (RPKM 61.8), CNS E18 (RPKM 6.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 11.73 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (21134202..21161281)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (21001245..21028224)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin-ligase RNF138 may regulate p53 protein expression to regulate the self-renewal and tumorigenicity of glioma stem cells.
Title: E3 ubiquitin-ligase RNF138 may regulate p53 protein expression to regulate the self-renewal and tumorigenicity of glioma stem cells.
RING finger 138 deregulation distorts NF-small ka, CyrillicB signaling and facilities colitis switch to aggressive malignancy.
Title: RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.
Rnf138 deficiency promotes the apoptosis of spermatogenic cells.
Title: Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA double-strand break processing involved in repair via single-strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA double-strand break processing involved in repair via single-strand annealing	ISO Inferred from Sequence Orthology more info
involved_in DNA double-strand break processing involved in repair via single-strand annealing	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF138

Names: RING-type E3 ubiquitin transferase RNF138

NP_001289934.1

EC 2.3.2.27

NP_001289940.1

EC 2.3.2.27

NP_062680.2

EC 2.3.2.27

NP_997506.1

EC 2.3.2.27

XP_006526180.1

EC 2.3.2.27

XP_006526181.1

EC 2.3.2.27

XP_006526182.1

EC 2.3.2.27

XP_011245277.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303005.1 → NP_001289934.1 E3 ubiquitin-protein ligase RNF138 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. These differences cause translation initiation at an alternate downstream start codon and result in an isoform (3) that is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC138611, AK013419, AK020748, AK136138, BB673818

UniProtKB/Swiss-Prot

Q9CQE0

UniProtKB/TrEMBL

Q9CSA3
NM_001303011.1 → NP_001289940.1 E3 ubiquitin-protein ligase RNF138 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.

Source sequence(s)

AC138611, AK004238, AK013419, AK020748, AK136138, BB673818

UniProtKB/TrEMBL

A0A3Q4EHU1

Related

ENSMUSP00000157123.2, ENSMUST00000234545.2

Conserved Domains (2) summary

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain

cl17238
Location:14 → 59

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_019706.3 → NP_062680.2 E3 ubiquitin-protein ligase RNF138 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AC138611, AK013419, AK020748, AK136138, BB673818

Consensus CDS

CCDS29089.1

UniProtKB/TrEMBL

A0A3Q4EHU1

Related

ENSMUSP00000072626.6, ENSMUST00000072847.12

Conserved Domains (2) summary

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain

cl17238
Location:14 → 59

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_207623.2 → NP_997506.1 E3 ubiquitin-protein ligase RNF138 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC138611, AK004238, AK013419, AK020748, AK136138, BB673818

Consensus CDS

CCDS29090.1

UniProtKB/Swiss-Prot

Q9CQE0, Q9WTR9, Q9WTS0

Related

ENSMUSP00000157047.2, ENSMUST00000234536.2

Conserved Domains (3) summary

cd16544
Location:14 → 59

RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins

pfam05605
Location:156 → 215

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

21134202..21161281

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246975.4 → XP_011245277.1 E3 ubiquitin-protein ligase RNF138 isoform X1

UniProtKB/Swiss-Prot

Q9CQE0, Q9WTR9, Q9WTS0

Related

ENSMUSP00000157102.2, ENSMUST00000234107.2

Conserved Domains (3) summary

cd16544
Location:14 → 59

RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins

pfam05605
Location:156 → 215

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain
XM_006526117.5 → XP_006526180.1 E3 ubiquitin-protein ligase RNF138 isoform X2

Conserved Domains (4) summary

cd00162
Location:18 → 57

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam05605
Location:137 → 196

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain

cl17238
Location:14 → 59

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006526118.5 → XP_006526181.1 E3 ubiquitin-protein ligase RNF138 isoform X3

UniProtKB/TrEMBL

A0A3Q4EHU1

Conserved Domains (2) summary

pfam18574
Location:80 → 112

zf_C2HC_14; C2HC Zing finger domain

cl17238
Location:14 → 59

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006526119.5 → XP_006526182.1 E3 ubiquitin-protein ligase RNF138 isoform X4

Conserved Domains (2) summary

pfam05605
Location:43 → 102

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

cl17238
Location:14 → 37

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain