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    APA1 bifunctional AP-4-A phosphorylase/ADP sulfurylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850307, updated on 9-Dec-2024

    Summary

    Official Symbol
    APA1
    Official Full Name
    bifunctional AP-4-A phosphorylase/ADP sulfurylase
    Primary source
    SGD:S000000555
    Locus tag
    YCL050C
    See related
    AllianceGenome:SGD:S000000555; FungiDB:YCL050C; VEuPathDB:YCL050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DTP1
    Summary
    Enables bis(5'-nucleosyl)-tetraphosphatase activity and sulfate adenylyltransferase (ADP) activity. Involved in nucleoside catabolic process and nucleotide biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See APA1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (37836..38801, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pbn1p Neighboring gene Lre1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001135.5

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    bifunctional AP-4-A phosphorylase/ADP sulfurylase
    NP_009880.2
    • AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      37836..38801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178695.1 → NP_009880.2  TPA: bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009880.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW6, P16550
      UniProtKB/TrEMBL
      A6ZTE4, B3LU34, B5VER2, C7GT05, C8Z439, G2W9X7, N1PAN8
      Conserved Domains (1) summary
      COG4360
      Location:2 → 310
      APA2; ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]
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