COX5A cytochrome c oxidase subunit Va [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COX5A
Official Full Name: cytochrome c oxidase subunit Va
Primary source: SGD:S000004997
Locus tag: YNL052W
See related: AllianceGenome:SGD:S000004997; FungiDB:YNL052W; VEuPathDB:YNL052W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See COX5A in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (531725..532186)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of isoenzymes cox5a and cox5b indicate that the elevated activity of cox5b in the rox1 mutant is not caused by exchange of isoforms.
Title: Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.
COX5a is switched off and COX5b is switched on when the O2 concentration drops below a threshold of 0.5 microM O2.
Title: Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase subunit Va

NP_014346.1

Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

531725..532186

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182891.1 → NP_014346.1 TPA: cytochrome c oxidase subunit Va [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014346.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1C7, P00424

UniProtKB/TrEMBL

A6ZS26, B3LNR3, C7GLU9, C8ZGH6, G2WM51, N1P4I7

Conserved Domains (1) summary

pfam02936
Location:34 → 152

COX4; Cytochrome c oxidase subunit IV