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    DCS2 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCS2
    Official Full Name
    5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
    Primary source
    SGD:S000005699
    Locus tag
    YOR173W
    See related
    AllianceGenome:SGD:S000005699; FungiDB:YOR173W; VEuPathDB:YOR173W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme inhibitor activity. Involved in cellular response to starvation and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DCS2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (657264..658325)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene sphinganine kinase LCB4 Neighboring gene Yrm1p Neighboring gene Med4p Neighboring gene lysophospholipid acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast. Malys N, et al. Nucleic Acids Res, 2004. PMID 15240832, Free PMC Article
    2. Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. Malys N, et al. J Mol Biol, 2006 Oct 20. PMID 16963086
    3. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. van Dijk E, et al. Proc Natl Acad Sci U S A, 2003 Oct 14. PMID 14523240, Free PMC Article
    4. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. Liu H, et al. EMBO J, 2002 Sep 2. PMID 12198172, Free PMC Article
    5. Functional analysis of mRNA scavenger decapping enzymes. Liu SW, et al. RNA, 2004 Sep. PMID 15273322, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that Dcs2 is a novel type of stress-induced regulatory protein that modulates m(7)GpppX pyrophosphatase activity.
      Title: Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA methylguanosine-cap decapping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
    NP_014816.2
    • m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      657264..658325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183592.1 → NP_014816.2  TPA: 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014816.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2M9, Q12123
      UniProtKB/TrEMBL
      C7GN54, N1NWQ1
      Conserved Domains (1) summary
      COG5075
      Location:3 → 329
      COG5075; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12123.3

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