SER1 O-phospho-L-serine:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SER1
Official Full Name: O-phospho-L-serine:2-oxoglutarate transaminase
Primary source: SGD:S000005710
Locus tag: YOR184W
See related: AllianceGenome:SGD:S000005710; FungiDB:YOR184W; VEuPathDB:YOR184W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADE9
Summary: Enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity. Involved in L-serine biosynthetic process and purine nucleobase biosynthetic process. Located in cytoplasm. Used to study Neu-Laxova syndrome 2 and PSAT deficiency. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SER1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (679357..680544)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-serine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-serine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serine family amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: O-phospho-L-serine:2-oxoglutarate transaminase

NP_014827.3

EC 2.6.1.52

3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

679357..680544

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183603.3 → NP_014827.3 TPA: O-phospho-L-serine:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014827.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2P0, P33330

UniProtKB/TrEMBL

B3LJL4, B5VS68, C7GLR0, G2WN57, N1NWQ6

Conserved Domains (1) summary

cd00611
Location:9 → 392

PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...