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    RMA1 putative tetrahydrofolate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RMA1
    Official Full Name
    putative tetrahydrofolate synthase
    Primary source
    SGD:S000001615
    Locus tag
    YKL132C
    See related
    AllianceGenome:SGD:S000001615; FungiDB:YKL132C; VEuPathDB:YKL132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable dihydrofolate synthase activity and tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in folic acid-containing compound biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RMA1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (193574..194866, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene metalloendopeptidase Neighboring gene Rci50p Neighboring gene She2p Neighboring gene myosin 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. Cherest H, et al. J Biol Chem, 2000 May 12. PMID 10799479
    2. Insights Into the Mechanism of Anticancer Drug Imatinib Revealed Through Multi-Omic Analyses in Yeast. Taymaz-Nikerel H, et al. OMICS, 2020 Nov. PMID 32991258
    3. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article
    4. Genome-Wide Studies of Rho5-Interacting Proteins That Are Involved in Oxidant-Induced Cell Death in Budding Yeast. Singh K, et al. G3 (Bethesda), 2019 Mar 7. PMID 30670610, Free PMC Article
    5. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables dihydrofolate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dihydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative tetrahydrofolate synthase
    NP_012790.1
    • Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      193574..194866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179698.1 → NP_012790.1  TPA: putative tetrahydrofolate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX64, P36001
      UniProtKB/TrEMBL
      A6ZZI9, G2WHQ6, N1P162
      Conserved Domains (1) summary
      COG0285
      Location:10 → 430
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36001.1

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