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    SPC1 signal peptidase complex subunit SPC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPC1
    Official Full Name
    signal peptidase complex subunit SPC1
    Primary source
    SGD:S000003770
    Locus tag
    YJR010C-A
    See related
    AllianceGenome:SGD:S000003770; FungiDB:YJR010C-A; VEuPathDB:YJR010C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (458077..458361, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene sulfate adenylyltransferase Neighboring gene Cal4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins. Yim C, et al. J Cell Sci, 2021 Jul 1. PMID 34125229, Free PMC Article
    2. The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae. Fang H, et al. J Biol Chem, 1996 Jul 12. PMID 8663399
    3. Yeast signal peptidase contains a glycoprotein and the Sec11 gene product. YaDeau JT, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1846444, Free PMC Article
    4. Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. Mullins C, et al. J Biol Chem, 1996 Nov 15. PMID 8910564
    5. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
      Title: Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to ER IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit SPC1
    NP_012544.1
    • Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      458077..458361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181667.1 → NP_012544.1  TPA: signal peptidase complex subunit SPC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWI6, P46965
      UniProtKB/TrEMBL
      A6ZPX8, B3LQB0, C7GWK1, C8ZBG6, G2WH22, N1P109
      Conserved Domains (1) summary
      pfam06645
      Location:16 → 85
      SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46965.1

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